Summary
The X gene product of human hepatitis B virus (HBV) trans-activates the HBV enhancer. In order to identify domains responsive to trans-activation by the X gene, we introduced a series of mutations into the HBV enhancer and assayed the enhancer activities in the presence of the X gene product. Our results suggest that the EP domain of the enhancer is essential for trans-activation by the X gene.
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Goodarzi, G., Ohno, H., Adams, R. et al. Mutational analysis of enhancer domains responsive to trans-activation by the X gene of human hepatitis B virus. Archives of Virology 114, 237–242 (1990). https://doi.org/10.1007/BF01310752
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DOI: https://doi.org/10.1007/BF01310752