Summary
Escherichia coli-derived human interferon-γ (rIFN-γ) inhibited the replication of human cytomegalovirus (HCMV) synergistically when combined with IFN-α. The induction of HCMV DNA polymerase was inhibited in rIFN-γ-treated cells. It is suggested that the induction of 2–5 A synthetase does not play an important role in the anti-HCMV actions of IFNs.
This is a preview of subscription content, log in via an institution to check access.
References
Holmes AR, Rasmussen L, Merigan TC (1978) Factors affecting the interferon sensitivity of human cytomegalovirus. Intervirol 9: 48–55
Meyers TD, McGuffin RW, Neiman PE, Singer JW, Thomas ED (1980) Toxicity and efficacy of human leukocyte interferon for treatment of cytomegalovirus pneumonia after marrow transplantation. J Infect Dis 141: 555–562
Neiman PE, Wasserman PB, Wentworth BB, Kao GF, Lehner KG, Storb R, Buckner CD, Clift RA, Fefer A, Fass L, Glucksberg H, Thomas ED (1973) Interstitial pneumonia and cytomegalovirus infection as complications of human marrow transplantation. Transplantation 15: 478–485
Nishiyama Y, Rapp F (1981) Enhanced capacity of DNA repair in human cytomegalovirus-infected cells. J Virol 38: 164–172
Nishiyama Y, Maeno K, Yoshida S (1983) Characterization of human cytomegalovirus-induced DNA polymerase and the associated 3′- to 5′-exonuclease. Virology 124: 221–231
Paez E, Esteban M (1984) Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system. Virology 134: 12–28
Rapp F (1980) Persistence and transmission of cytomegalovirus. In:Fraenkel-Conrat H, Wagner RR (eds) Comprehensive virology, vol 16. Plenum Press, New York, pp 193–232
Spector SA, Tyndall M, Kelley E (1982) Effects of acyclovir combined with other antiviral agents on human CMV. Am J Med 73: 36–39
Stinski MF, Thomsen DR, Rodriguez JE (1982) Synthesis of human cytomegalovirus-specified RNA and protein in interferon-treated cells at early times after infection. J Gen Virol 60: 261–270
Wade JC, McGuffin RW, Springmeyer SC, Newton B, Singer JW, Meyers JD (1983) Treatment of cytomegaloviral pneumonia with high-dose acyclovir and human leukocyte interferon. J Infect Dis 148: 557–562
Author information
Authors and Affiliations
Additional information
With 2 Figures
Rights and permissions
About this article
Cite this article
Yamamoto, N., Shimokata, K., Maeno, K. et al. Effect of recombinant human interferon γ against human cytomegalovirus. Archives of Virology 94, 323–329 (1987). https://doi.org/10.1007/BF01310726
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01310726