Summary
Camptothecin (CPT), a specific inhibitor of DNA topoisomerase I, effectively inhibited the replication of herpes simplex virus type 2 (HSV-2). CPT was found to reduce the level of immediate early viral mRNA in a dose-response manner. On the other hand, we could not find any evidence that a novel DNA topoisomerase I was induced in HSV-2-infected cells. Our observations suggest that host cell DNA topoisomerase I is involved in the replication of HSV-2.
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Yamada, Y., Yamamoto, N., Maeno, K. et al. Role of DNA topoisomerase I in the replication of herpes simplex virus type 2. Archives of Virology 110, 121–127 (1990). https://doi.org/10.1007/BF01310708
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DOI: https://doi.org/10.1007/BF01310708