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Neurovirulence of an herpes simplex type 1 thymidine kinase negative mutant determined by virus biochemical defect and host immune system in mice

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Summary

While the biochemical defect of the thymidine kinase negative HSV-1 mutant restricts virus replication in mouse neural tissue, and thereby reduces neurovirulence, the host immune system also limits HSV-1 TK-replication in permissive glial cells in immunocompetent mice, and reduces neurovirulence.

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References

  1. Cottral, G. E.: In: Manual of Standardized Methods for Veterinary Microbiology, 81. Ithaca, N. Y.: Cornell University Press 1978.

    Google Scholar 

  2. Das Gupta, U. B., Summers, W. V.: Ultraviolet reactivation of Herpes Simplex virus is mutagenic and inducible in mammalian cells. Proc. Natl. Acad. Sci. U.S.A.75, 2378 (1978).

    Google Scholar 

  3. Field, H. J., Wildy, P.: The pathogenicity of thymidine kinase-deficient mutants of Herpes Simplex virus in mice. J. Hyg.81, 267 (1978).

    Google Scholar 

  4. Field, H. J., Anderson, J. R., Wildy, P.: A typical patterns of neural infection produced in mice by drug-resistant strains of Herpes Simplex virus. J. gen. Virol.59, 91–99 (1982).

    Google Scholar 

  5. Finney, D. J.: In: Statistical Method in Biological Assay, 3rd ed., 81. New York: Macmillan 1978.

    Google Scholar 

  6. Gordon, Y. J., Gilden, D. M., Becker, Y.: HSV-1 thymidine kinase promotes virulence and latency in the mouse. Invest. Ophthalmol. Vis. Sci.24, 599 (1983).

    Google Scholar 

  7. Gordon, Y. J., Gilden, D. M., Shtram, Y., Asher, Y., Tabor, E., Wellish, M., Delvin, M., Snipper, D., Hadar, J., Becker, Y.: A low thymidine kinase-producing mutant of herpes simplex virus type 1 causes latent trigeminal ganglia infections in mice. Arch. Virol.76, 39 (1983).

    Google Scholar 

  8. Huang, D. D., Abrams, G. D., Maassab, H. F.: Neurological involvement in mice after injection with a cold-adapted Herpes Simplex type 2 virus. Infect. Immun.35, 1070–1078 (1982).

    Google Scholar 

  9. Jamieson, A. T., Gentry, G. A., Subak-Sharpe, J. H.: Induction of both thymidine and deoxycytidine kinase activity by Herpes viruses. J. gen. Virol.24, 465 (1974).

    Google Scholar 

  10. Levitt, J., Becker, Y.: The effect of cytosine arabinoside on the replication of herpes simplex virus. Virology31, 129 (1967).

    Google Scholar 

  11. Price, R. W., Khan, A.: Resistance of peripheral autonomic neurons toin vivo productive infection by herpes simplex virus mutants deficient in thymidine kinase activity. Infect. Immun.34, 571–580 (1981).

    Google Scholar 

  12. Tenser, R. B., Dunstan, M. E.: Herpes Simplex virus thymidine kinase expression in infection of the trigeminal ganglion. Virology99, 417–422 (1979).

    Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, U.S.A.

    Y. J. Gordon & P. L. Simon

  2. Department of Microbiology, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, U.S.A.

    J. A. Armstrong

  3. Eye and Ear Hospital, 230 Lothrop Street, 15213, Pittsburgh, PA, U.S.A.

    Y. J. Gordon

Authors
  1. Y. J. Gordon
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  2. P. L. Simon
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  3. J. A. Armstrong
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Gordon, Y.J., Simon, P.L. & Armstrong, J.A. Neurovirulence of an herpes simplex type 1 thymidine kinase negative mutant determined by virus biochemical defect and host immune system in mice. Archives of Virology 80, 225–229 (1984). https://doi.org/10.1007/BF01310662

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  • DOI: https://doi.org/10.1007/BF01310662

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