Summary
A non-neutralizing monoclonal antibody (YO-60) against human rotavirus was found to be directed to VP2 (90,000-dalton protein), one of the two major components of the inner capsid. The reactivity patterns of the YO-60 antibody were very similar, though not identical, to those of subgroup II-specific YO-5 monoclonal antibody directed to VP6 (42,000-dalton protein), the other major component of the inner capsid.
These results indicated the possible presence of a subgroup-specific antigen on VP2 in addition to the one on VP6.
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This study was supported in part by a grant no. 58570213 from the Ministry of Education, Science and Culture of Japan.
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Taniguchi, K., Urasawa, T. & Urasawa, S. Reactivity patterns to human rotavirus strains of a monoclonal antibody against VP2, a component of the inner capsid of rotavirus. Archives of Virology 87, 135–141 (1986). https://doi.org/10.1007/BF01310550
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DOI: https://doi.org/10.1007/BF01310550