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Demonstration of non-degraded aleutian disease virus (ADV) proteins in lung tissue from experimentally infected mink kits

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Summary

Isolates of ADV replicate to rather high quantities in lungs from neonatally infected mink kits. The virus was analysed for polypeptide composition, and for the first time high molecular weight polypeptides have been observed inin vivo produced ADVs. These polypeptides are analogous to those ofin vitro produced ADVs. The molecular weights of the structural polypeptides of the low virulence Pullman ADV and the highly virulent DK and Utah I isolates of ADV were found to be 88kD and 78kD andin vivo produced ADV-G polypeptides were found to be 85kD and 75kD, the same molecular weights as those described forin vitro produced ADV-G. Presence of the ADV coded, non-structural polypeptide with the molecular weight of 71kD (p71) was also demonstrated in the lung tissue from mink kits.

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Authors and Affiliations

  1. Department of Pathology, Royal Veterinary and Agricultural University, Copenhagen, Denmark

    S. Alexandersen

  2. Department of Veterinary Virology and Immunology, Royal Veterinary and Agricultural University, Copenhagen, Denmark

    Å. Uttenthal-Jensen & B. Aasted

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  1. S. Alexandersen
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  2. Å. Uttenthal-Jensen
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  3. B. Aasted
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Alexandersen, S., Uttenthal-Jensen, Å. & Aasted, B. Demonstration of non-degraded aleutian disease virus (ADV) proteins in lung tissue from experimentally infected mink kits. Archives of Virology 87, 127–133 (1986). https://doi.org/10.1007/BF01310549

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  • DOI: https://doi.org/10.1007/BF01310549

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