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Role of Langerhans cells in the infection of the guinea-pig epidermis with foot-and-mouth disease virus

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Summary

In guinea-pig infected with foot-and-mouth disease virus (FMDV), Langerhans cells in the foot pads increase in number and show viral antigens 24 hours post-inoculation, preceding appearance of virus in epithelial cells and vesiculation. This observation suggests that Langerhans cells may be engaged in virus transport from the blood to the non vascularized epidermis.

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Authors and Affiliations

  1. Cátedra de Patologia II, Universidad Nacional de La Plata, La Plata, Argentina

    Wanda di Girolamo, Margarita Salas & R. P. Laguens

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  1. Wanda di Girolamo
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  2. Margarita Salas
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  3. R. P. Laguens
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di Girolamo, W., Salas, M. & Laguens, R.P. Role of Langerhans cells in the infection of the guinea-pig epidermis with foot-and-mouth disease virus. Archives of Virology 83, 331–336 (1985). https://doi.org/10.1007/BF01309929

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  • DOI: https://doi.org/10.1007/BF01309929

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