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Immunogenicity of purified glycoprotein gB of herpes simplex virus

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Summary

The efficacy of a herpes simplex virus (HSV) component vaccine consisting of viral glycoprotein gB was examined in a mouse system. Immunization of mice with HSV type 1 (HSV-1) gB emulsified in Freund's complete adjuvant or with HSV-1 gB adsorbed to aluminum gel was fully protective against subsequent challenge with HSV-1 or HSV type 2. Latent infection in the trigeminal ganglion was also prevented by immunization with gB.

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Authors and Affiliations

  1. The Chemo-Sero-Therapeutic Research Institute, Kumamoto, Japan

    Y. Kino, T. Eto, K. Nishiyama & N. Ohtomo

  2. Department of Virology, School of Medicine, Kyushu University, Fukuoka, Japan

    R. Mori

Authors
  1. Y. Kino
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  2. T. Eto
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  3. K. Nishiyama
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  4. N. Ohtomo
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  5. R. Mori
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Kino, Y., Eto, T., Nishiyama, K. et al. Immunogenicity of purified glycoprotein gB of herpes simplex virus. Archives of Virology 89, 69–80 (1986). https://doi.org/10.1007/BF01309880

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  • DOI: https://doi.org/10.1007/BF01309880

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