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Role of Langerhans cells and other dendritic cells in viral diseases

  • Brief Review
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Summary

Langerhans cells are part of a vast system of potent antigen-presenting cells known under the name of dendritic cells. During the last decade, much has been learned on dendritic cell involvement in the immune response to infectious diseases. This review briefly summarizes our current understanding of the role played by Langerhans cells and other dendritic cells in the pathogenesis of DNA and RNA virus infections. These data may form the basis for the development of innovative approaches in the diagnosis, prevention, and treatment of viral diseases.

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References

  1. Aiba S, Katz SI (1990) Phenotypic and functional characteristics of in vivo-activated Langerhans cells. J Immunol 145: 2791–2796

    Google Scholar 

  2. Ambe K, Mori M, Enjoji M (1989) S-100 protein-positive dendritic cells in colorectal adenocarcinomas. Cancer 63: 496–503

    Google Scholar 

  3. Asbell PA, Kamenar T (1987) The response of Langerhans cells in the cornea to herpetic keratitis. Curr Eye Res 6: 179–182

    Google Scholar 

  4. Bartosik J (1992) Cytomembrane-derived Birbeck granules transport horseradish peroxidase to the endosomal compartment in the human Langerhans cells. J Invest Dermatol 99: 53–58

    Google Scholar 

  5. Becker D, Neiß U, Neis S, Reske K, Knop J (1992) Contact allergens modulate the expression of MHC class II molecules on murine epidermal Langerhans cells by endocytic mechanisms. J Invest Dermatol 98: 700–705

    Google Scholar 

  6. Becker Y (1990) Rationale for anti-AIDS chemotherapy directed at HIV-1 infected dendritic cells in seropositive individuals prior to the appearance of ARC and AIDS. J Chemother 2: 152–155

    Google Scholar 

  7. Becker Y, Sprecher E (1989) Langerhans cells in vaccinia virus infection in mouse skin. Arch Virol 107: 307–313

    Google Scholar 

  8. Belsito DV, Sanchez MR, Baer RL, Valentine F, Thorbecke GJ (1984) Reduced Langerhans cell Ia antigen and ATPase activity in patients with the acquired immunodeficiency syndrome. N Engl J Med 310: 1279–1282

    Google Scholar 

  9. Berger R, Gartner S, Rappersberger K, Foster CA, Wolff K, Stingl G (1992) Isolation of human immunodeficiency virus type 1 from human epidermis: virus replication and transmission studies. J Invest Dermatol 99: 271–277

    Google Scholar 

  10. Bonneau RH, Jennings SR (1989) Modulation of acute and latent herpes simplex virus infection in C57BL/6 mice by adoptive transfer of immune lymphocytes with cytolytic activity. J Virol 63: 1480–1486

    Google Scholar 

  11. Braathen LR, Berle E, Mobech-Hansen U, Thorsby E (1980) Activation of human T lymphocytes to herpes simplex virus. Acta Derm Venereol (Stockh) 60: 381–387

    Google Scholar 

  12. Braathen LR, Ramirez G, Kunze RO, Mork C, Strand O (1991) HIV infection of skin Langerhans cells. In: Becker Y (ed) Skin Langerhans (dendritic) cells in virus infections and AIDS. Kluwer Academic Publishers, Boston, pp 131–140

    Google Scholar 

  13. Brodsky FM, Guagliardi LE (1991) The cell biology of antigen processing and presentation. Annu Rev Immunol 9: 707–744

    Google Scholar 

  14. Brown RC, Brown JE, Ayowa OB (1992) Vaginal inflammation in Africa. N Engl J Med 327: 572

    Google Scholar 

  15. Cameron PU, Forsum U, Teppler H, Granelli-Piperno A, Steinman RM (1992) During HIV-1 infection, most blood dendritic cells are not productively infected and can induce allogeneic CD4+ T cell clonal expansion. Clin Exp Immunol 88: 226–236

    Google Scholar 

  16. Cameron PU, Freudenthal PS, Barker JM, Gezelter S, Inaba K, Steinman RM (1992) Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science 257: 383–387

    Google Scholar 

  17. Chakrabati S, Robert-Gurrof M, Wong-Staal F, Gallo RC, Moss B (1986) Expression of the HTLV-III envelope gene by a recombinant vaccinia virus. Nature 320: 535–537

    Google Scholar 

  18. Chardonnet Y, Beauve P, Viac J, Schmidt D (1983) T-cell subsets and Langerhans cells in wart lesions. Immunol Lett 6: 191–196

    Google Scholar 

  19. Cherrie AH, Anderson K, Wertz GW, Openshaw PJM (1992) Human cytotoxic T cells stimulated by antigen on dendritic cells recognize the N, SH, M, 22 K and 1 b proteins of respiratory syncitial virus. J Virol 66: 2102–2110

    Google Scholar 

  20. Cockerell CJ (1991) Human immunodeficiency virus infection and the skin. A crucial interface. Arch Intern Med 151: 1295–1303

    Google Scholar 

  21. Cohen PJ, Cohen PA, Rosenberg SA, Katz SI, Mulé JJ (1992) Murine epidermal Langerhans cells and splenic dendritic cells process and present tumor antigens to primed T cells. J Invest Dermatol 98: 594

    Google Scholar 

  22. Cruz PC, Bergstresser PR (1989) Ultraviolet radiation, Langerhans cells and skin cancer. Arch Dermatol 125: 975–979

    Google Scholar 

  23. Cruz PD, Bergstresser PR (1990) Antigen processing and presentation by epidermal Langerhans cells. Dermatol Clin 8: 633–647

    Google Scholar 

  24. Cumberbatch M, Illingworth I, Kimber I (1991) Antigen-bearing dendritic cells in the draining lymph nodes of contact sensitized mice: cluster formation with lymphocytes. Immunology 74: 139–145

    Google Scholar 

  25. Cumberbatch M, Gould SJ, Peters SW, Kimber I (1991) MHC class II expression by Langerhans cells and lymph node dendritic cells: possible evidence for maturation of Langerhans cells following contact sensitization. Immunology 74: 414–419

    Google Scholar 

  26. Cumberbatch M, Kimber I (1992) Dermal tumor necrosis factor-α induces dendritic cell migration to draining lymph nodes and possibly provides one stimulus for Langerhans cell migration. Immunology 75: 257–263

    Google Scholar 

  27. Daniels TE, Greenspan D, Greenspan JS, Lenette E, Schiodt, Petersen V, de Suza Y (1987) Absence of Langerhans cells in oral leukoplakia, an AIDS-associated lesion. J Invest Dermatol 89: 178–182

    Google Scholar 

  28. David D, Yadin H, Becker Y (1992) Isolation of bovine skin Langerhans cells and maintenance of their viability in vitro. Isr J Vet Sci 47: 11–16

    Google Scholar 

  29. De Panfilis G, Manara GC, Ferrari C, Torresani C (1991) Adhesion molecules on the plasma membrane of epidermal Langerhans cells III. Keratinocytes and Langerhans cells constitutively express the lymphocyte function-associated antigen 3. J Invest Dermatol 96: 512–517

    Google Scholar 

  30. Dezutter-Dambuyant C, Schmitt DA, Dusserre N, Hanau D, Kolbe HV, Kieny MP, Cazenave JP, Schmitt D, Pasquali JL, Olivier R, Gazzolo L, Thivolet J (1991) Interaction of human epidermal Langerhans cells with HIV-1 envelope proteins (gp 120 and gp 160 s) involves a receptor-mediated endocytosis independent of the CD4 T4A epitope. J Dermatol 18: 377–392

    Google Scholar 

  31. DiGirolamo W, Sela M, Jaguens RP (1985) Role of Langerhans cells in the infection of the guinea pig epidermis with foot and mouth disease virus. Arch Virol 83: 331–336

    Google Scholar 

  32. Dréno B, Milpied B, Bignon JD, Stalder JF, Litoux P (1988) Prognostic value of Langerhans cells in the epidermis of HIV patients. Br J Dermatol 118: 481–486

    Google Scholar 

  33. Dusserre N, Dezutter-Dambuyant C, Mallet F, Delorme P, Philit F, Ebersold A, Desgranges C, Thivolet J, Schmitt D (1992) In vitro HIV-1 entry and replication in Langerhans cells may clarify the HIV-1 genome detection by PCR in epidermis of seropositive patients. J Invest Dermatol 99: 99 s-102 s

    Google Scholar 

  34. French MAH, Cameron PU, Smyth LA, Dawkins RL (1990) Correction of human immunodeficiency virus-associated depression of delayed-type hypersensitivity (DTH) after zidovudine therapy: DTH, CD4+ T-cell numbers and epidermal Langerhans cell density are independent variables. Clin Immunol Immunopathol 55: 86–96

    Google Scholar 

  35. Furihata M, Ohtsuki Y, Ido E, Iwata J, Sonobe H, Araki K, Ogoshi S, Ohmori K (1992) HLA-DR antigen and S-100 protein-positive dendritic cells in esophageal squamous cell carcinoma - their distribution in relation to prognosis. Virchows Arch [B] 61: 409–414

    Google Scholar 

  36. Gallo O, Libonati GA, Gallina E, Fini-Storchi O, Giannini A, Urso C, Bondi R (1991) Langerhans cells related to prognosis in patients with laryngeal carcinoma. Arch Otolaryngol Head Neck Surg 117: 1007–1010

    Google Scholar 

  37. Ghaznawie M, Papadimitriou JM, Heenan PJ (1989) Reduced density and morphologic alterations of la and ADPase positive Langerhans cells after low-protein diet. Br J Dermatol 120: 341–349

    Google Scholar 

  38. Gorrel MD, Brandon MR, Sheffer D, Adams RJ, Narayan O (1992) Ovine lentivirus is macrophagetropic and does not replicate productively in T lymphocytes. J Virol 66: 2679–2688

    Google Scholar 

  39. Gothelf Y, Dinarello CA, Yamin M, Sharon N, Milner Y, Gazit E (1989) IL-1 production by T6 (CD1 a) positive cord blood mononuclear cells (Langerhans cell precursors?). Lymphokine Res 8: 373–382

    Google Scholar 

  40. Grabbe S, Bruvers S, Gallo RL, Knisely TL, Nazareno R, Granstein RD (1991) Tumor antigen presentation by murine epidermal cells. J Immunol 146: 3656–3661

    Google Scholar 

  41. Grabbe S, Bruvers S, Lindgren AM, Hosoi J, Tan KC, Granstein RD (1992) Tumor antigen presentation by epidermal antigen-presenting cells in the mouse: modulation by granulocyte-macrophage colony stimulating factor, tumor necrosis factor alpha and ultraviolet radiation. J Leuk Biol 52: 209–217

    Google Scholar 

  42. Gregg DA, Soroka DS, Mebus CA (1991) Langerhans cell and interdigitating cell infection in African swine fever. In: Becker Y (ed) Skin Langerhans (dendritic) cells in virus infections and AIDS. Kluwer Academic Publishers, Boston, pp 289–298

    Google Scholar 

  43. Gruner S, Diezel W, Strunk D, Zwirner A, Sönnichen N, Anhalt GJ (1990) Stimulation of the recruitment of epidermal Langerhans cells by splenopentin. Arch Dermatol Res 281: 526–529

    Google Scholar 

  44. Halliday GM, Dickinson JL, Muller HK (1989) Retinoic acid protects Langerhans cells from the effect of the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. Immunology 67: 298–302

    Google Scholar 

  45. Hawthron RJS, Murdoch JB, McLean AB, McKie RM (1988) Langerhans cells and subtypes of human papillomavirus in cervical intraepithelial neoplasia. Br Med J 297: 643–646

    Google Scholar 

  46. Hayashi Y, Aurelian L (1986) Immunity to herpes simplex type 2: viral antigen presenting capacity of epidermal cells and its impairment by ultraviolet irradiation. J Immunol 136: 1987–1092

    Google Scholar 

  47. Heindricks RL, Janowicz M, Tumpey TM (1992) Critical role of corneal Langerhans cells in the CD 4- but not CD 8-mediated immunopathology in herpes simplex virus-1-infected mouse corneas. J Immunol 148: 2522–2529

    Google Scholar 

  48. Hengel H, Lindner M, Wagner H, Heeg K (1987) Frequency of herpes simplex virus-specific murine cytotoxic T lymphocyte precursors in mitogen- and antigen-driven primary in vitro responses. J Immunol 139: 4196–4202

    Google Scholar 

  49. Heufler CH, Parkinson EK, Graham GJ, Koch F, Topar G, Kämpgen E, Romani N, Pragnell IB, Schuler G (1992) Cytokine gene expression in murine epidermal Langerhans cells: MIP-1α is a major product and inhibits the proliferation of keratinocyte stem cells. J Invest Dermatol 98: 515

    Google Scholar 

  50. Hill TJ, Blyth WA (1976) An alternative theory of herpes simplex recurrence and a possible role of prostaglandins. Lancet i: 397–399

    Google Scholar 

  51. Hill TJ, Harbour DA, Blyth WA (1980) Recovery of herpes simplex virus from the skin of clinically normal mice during latent infection. J Gen Virol 47: 205–207

    Google Scholar 

  52. Hughes RA, Macatonia SE, Rowe IF, Keat AC, Knight SC (1990) Detection of human immunodeficiency virus DNA in dendritic cells from the joints of patients with aseptic arthritis. Br J Rheumatol 29: 166–170

    Google Scholar 

  53. Inaba K, Metlay JP, Crowley MT, Steinman RM (1990) Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J Exp Med 172: 631–640

    Google Scholar 

  54. Inaba K, Steinman RM, Witmer-Pack M, Aya H, Inaba M, Sudo T, Wolpe S, Schuler G (1992) Identification of proliferating dendritic cell precursors in mouse blood. J Exp Med 175: 1157–1167

    Google Scholar 

  55. Jagger MJ, Atherton S, Bradley D, Streilein JW (1991) Herpetic stromal keratitis: less reversibility in the presence of Langerhans cells in the central cornea. Curr Eye Res [Suppl] 10: 69–75

    Google Scholar 

  56. Jessurun J, Romo-Garcia J, Lopez-Denis O, Olivera-Rabiela JE (1990) Crusted scabies in a patient with the acquired immunodeficiency syndrome. Virchows Arch [A] 416: 461–463

    Google Scholar 

  57. Kalter DC, Greenhouse JJ, Orenstein JM, Schnittman SM, Gendelman HE, Meltzer MS (1991) Epidermal Langerhans cells are not principal reservoirs of virus in HIV disease. J Immunol 146: 3396–3404

    Google Scholar 

  58. Kämpgen E, Koch N, Stöger P, Heufler C, Schuler G, Romani N (1991) Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain and antigen-processing capacity are down-regulated upon culture. Proc Natl Acad Sci USA 88: 3014–3018

    Google Scholar 

  59. Kanitakis J, Marchand C, Su H, Thivolet J, Zambruno G, Schmitt D, Gazollo L (1989) Immunohistochemical study of normal skin of HIV-1 infected patients show no evidence of infection of epidermal Langerhans cells by HIV. AIDS Res Hum Retroviruses 5: 293–302

    Google Scholar 

  60. Kanitakis J, Escaich S, Trepo C, Thivolet J (1991) Detection of human immunodeficiency virus-DNA and RNA in the skin of HIV-infected patients using the polymerase chain reaction. J Invest Dermatol 97: 91–96

    Google Scholar 

  61. Kanzler ZH, Rasmussen JE (1988) Isotretinoin therapy for recurrent herpes simplex lesions. Arch Dermatol 124: 323–325

    Google Scholar 

  62. Kaplan G, Walsh G, Laarni SG, Meyn P, Burkhardt ERA, Abalos RM, Barker J, Frindt PA, Tranquilino TF, Celona R, Cohn ZA (1992) Novel responses of human skin to intradermal recombinant granulocyte/macrophage-colony stimulating factor: Langerhans cell recruitment, keratinocyte growth and enhanced wound healing. J Exp Med 175: 1717–1728

    Google Scholar 

  63. Kast WM, Boog CPJ, Roep BO, Voordouw AC, Melief CJM (1988) Failure or success in the restoration of virus-specific cytotoxic T lymphocyte response defects by dendritic cells. J Immunol 140: 3186–3193

    Google Scholar 

  64. Kay LA (1987) Immunology of human skin and susceptibility to HIV infection. Lancet ii: 166

    Google Scholar 

  65. Knight SC, Macatonia SE (1988) Dendritic cells and viruses. Immunol Lett 19: 177–182

    Google Scholar 

  66. Knight SC, Patterson D, Macatonia SE (1991) Stimulatory and immunosuppressive effects of infection of dendritic cells with HIV-1. Immunol Lett 30: 212–218

    Google Scholar 

  67. Knight SC, Macatonia SE (1991) Effect of HIV on antigen-presentation by dendritic cells and macrophages. Res Virol 142: 123–128

    Google Scholar 

  68. Knight SC, Macatonia SE, Gomples M, Pinching AJ, Patterson S (1992) Zidovudine reverses the defect in dendritic cells in HIV infection. AIDS 6: 231–232

    Google Scholar 

  69. Knop J, Enk A, Heremans H (1988) Release of interferon-γ by epidermal Langerhans cells. J Invest Dermatol 90: 246

    Google Scholar 

  70. Krueger GG, Mansoor E (1984) Biology of Langerhans cells: analysis by experiments to deplete Langerhans cells from human skin. J Invest Dermatol 82: 613–618

    Google Scholar 

  71. Langhoff E, Terwilliger EF, Bos HJ, Kalland KH, Poznansky MC, Bacon OML, Haseltine WA (1991) Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures. Proc Natl Acad Sci USA 88: 7998–8002

    Google Scholar 

  72. Laor O, Torgersen H, Yadin H, Becker Y (1992) Detection of FMDV RNA by the polymerase chain reaction. J Virol Methods 36: 197–208

    Google Scholar 

  73. Larrick JW, Morhenn V, Chiang YL, Shi T (1989) Activated Langerhans cells release tumor necrosis factor. J Leuk Biol 45: 429–433

    Google Scholar 

  74. Larsen HS, Feng M, Horohov DW, Moore RN, Rouse BT (1984) Role of T lymphocyte subsets in recovery from herpes simplex virus infection. J Virol 50: 56–60

    Google Scholar 

  75. Larsen CP, Steinman RM, Witmer-Pack M, Hankins DF, Morris PJ, Austyn JM (1990) Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med 172: 1483–1493

    Google Scholar 

  76. Lehner T, Hussain L, Wilson J, Chapman M (1991) Mucosal transmission of HIV. Nature 353: 709

    Google Scholar 

  77. Leonard J, Khillan JS, Gendelman HE, Adachi A, Lorenzo S, Westphal H, Martin MA, Meltzer MS (1989) The human immunodeficiency virus long terminal repeat is preferentially expressed in Langerhans cells in transgenic mice. AIDS Res Hum Retroviruses 5: 421–430

    Google Scholar 

  78. Le Varlet B, Dezutter-Dambuyant C, Staquet MJ, Delorme P, Schmitt D (1991) Human epidermal Langerhans cells express integrins of the β1 subfamily. J Invest Dermatol 96: 518–522

    Google Scholar 

  79. Lewkowicz-Moss SJ, Shimeld C, Lipworth K, Hill TJ, Blyth WA, Easty DL (1987) Quantitative studies on Langerhans cells in mouse corneal epithelium following infection with herpes simplex virus. Exp Eye Res 45: 127–140

    Google Scholar 

  80. Lowe J, MacLennan KA, Powe DG, Pound JD, Palmer JB (1989) Microglial cells in human brain have phenotypic characteristics related to possible function as dendritic antigen-presenting cells. J Pathol 159: 143–149

    Google Scholar 

  81. Lusso P, Ensoli B, Markham PD, Ablashi DV, Salahuddin SZ, Tschachler E, Wong-Staal F, Gallo RC (1989) Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6. Nature 337: 370–373

    Google Scholar 

  82. Macatonia SE, Taylor PM, Knight SC, Askonas BA (1989) Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro. J Exp Med 169: 1255–1264

    Google Scholar 

  83. Macatonia SE, Patterson S, Knight SC (1989) Suppression of immune responses by dendritic cells infected with HIV. Immunology 67: 285–289

    Google Scholar 

  84. Macatonia SE, Lau R, Patterson S, Pinching AJ, Knight SC (1990) Dendritic cell infection, depletion and dysfunction in HIV-infected individuals. Immunology 71: 38–45

    Google Scholar 

  85. Macatonia SE, Patterson S, Knight SC (1991) Primary proliferative and cytotoxic T-cell response to HIV induced in vitro by human dendritic cells. Immunology 74: 399–406

    Google Scholar 

  86. Macatonia SE, Gompels M, Pinching AJ, Patterson S, Knight SC (1992) Antigen-presentation by macrophages but not by dendritic cells in human immunodeficiency virus (HIV) infection. Immunology 75: 576–581

    Google Scholar 

  87. Manca F (1992) Galactose receptors and presentation of HIV envelope glycoprotein to specific human T cells. J Immunol 148: 2278–2282

    Google Scholar 

  88. Matzinger P, Guerder S (1989) Does T-cell tolerance require a dedicated antigen-presenting cell? Nature 338: 74–76

    Google Scholar 

  89. McArdle JP, Muller HK (1986) Quantitative assessment of Langerhans cells in human cervical intraepithelial neoplasia and wart virus infection. Am J Obstet Gynecol 154: 509–515

    Google Scholar 

  90. Miller C, Gardner MB (1991) AIDS and mucosal immunity: usefulness of the SIV macaque model of genital mucosal transmission. J Acquir Immune Defic Syndr 4: 1169–1172

    Google Scholar 

  91. Metlay JP, Puré E, Steinman RM (1989) Control of the immune response at the level of antigen-presenting cells: a comparison of the function of dendritic cells and B cells. Adv Immunol 47: 45–116

    Google Scholar 

  92. Morelli AE, Ronchetti RD, Secchi AD, Cufre MA, Paredes A, Fainboim L (1992) Assessment by planimetry of Langerhans cell density in penile epithelium with human papillomavirus infection: changes observed after topical treatment. J Urol 147: 1268–1273

    Google Scholar 

  93. Morris HHB, Gatter KC, Sykes G, Casemore V, Mason DY (1983) Langerhans cells in human cervical epithelium: effects of wart virus infection and intraepithelial neoplasia. Br J Obstet Gynecol 90: 412–420

    Google Scholar 

  94. Mosca JD, Bednarik DP, Raj NBK, Rosen CA, Sodroski JG, Haseltine WA, Pitha PM (1987) Herpes simplex virus type 1 can reactivate transcription of latent human immunodeficiency virus. Nature 325: 67–70

    Google Scholar 

  95. Müller H, Falk S, Stutte HJ (1987) Accessory cells as primary target of human deficiency virus HIV infection. J Clin Pathol 39: 1161

    Google Scholar 

  96. Nagao S, Inaba S (1976) Langerhans cells at the site of vaccinia virus inoculation. Arch Dermatol Res 256: 23–31

    Google Scholar 

  97. Naher H, Schule T, Petzoldt D (1992) Evidence for genetic variants from detection of HIV DNA. Lancet ii: 519–520

    Google Scholar 

  98. Nickoloff BJ, Karabin GD, Barker JN, Griffiths CE, Sarma V, Mitra RS, Elder JT, Kunkel SL, Dixit VM (1991) Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-α in psoriasis. Am J Pathol 138: 129–140

    Google Scholar 

  99. Niedecken H, Lutz G, Bauer R, Kreysel HW (1987) Langerhans cells as primary targets and vehicle for transmission of HIV. Lancet ii: 519–520

    Google Scholar 

  100. Nonacs R, Humborg C, Tam JP, Steinman RM (1992) Mechanisms of mouse spleen dendritic cell function in the generation of influenza specific cytolytic T lymphocytes. J Exp Med 176: 519–529

    Google Scholar 

  101. Ogushi M, Komura J, Tagami H, Ofuji S (1981) Ultrastructural studies of spontaneously regressing plane warts. Langerhans cells show marked activation. Arch Dermatol Res 271: 55–61

    Google Scholar 

  102. Otani T, Mori R (1987) The effects of ultraviolet irradiation of the skin on herpes simplex virus infection: alteration in immune function mediated by epidermal cells and in the course of infection. Arch Virol 96: 1–15

    Google Scholar 

  103. Patterson S, Knight SC (1987) Susceptibility of human peripheral blood dendritic cells to infection by human immunodeficiency virus. J Gen Virol 68: 1177–1181

    Google Scholar 

  104. Patterson S, Gross J, Bedford P, Knight SC (1991) Morphology and phenotype of dendritic cells from peripheral blood and their productive and non-productive infection with human immunodeficiency virus type 1. Immunology 72: 361–367

    Google Scholar 

  105. Patterson S, Macatonia SE, Gross J, Bedford P, Knight SC (1991) HIV infection of peripheral blood dendritic cells. In: Becker Y (ed) Skin Langerhans (dendritic) cells in virus infection and AIDS. Kluwer Academic Publishers, Boston, pp 141–156

    Google Scholar 

  106. Pepose JS (1989) The relationship of corneal Langerhans cells to herpes simplex antigens during dendritic keratitis. Curr Eye Res 8: 851–858

    Google Scholar 

  107. Phillip W, Göttinger W (1991) T6-positive Langerhans cells in diseased corneas. Invest Ophthalmol Vis Sci 32: 2492–2497

    Google Scholar 

  108. Rappersberger K, Gartner S, Schenk P, Stingl G, Groh V, Tschaler E, Mann DL, Wolff K, Konrad K, Popovic M (1988) Langerhans cells are an actual site of HIV-1 replication. Intervirology 29: 185–194

    Google Scholar 

  109. Redfield RR, Wright DC, James WD, Jones TS, Brown C, Burke DS (1987) Disseminated vaccinia in a military recruit with human immunodeficiency virus disease. N Engl J Med 316: 673–676

    Google Scholar 

  110. Rheins LA, Nordlund JJ (1986) Modulation of the population density of identifiable epidermal Langerhans cells associated with enhancement or suppression of cutaneous immune reactivity. J Immunol 136: 867–876

    Google Scholar 

  111. Riccardi R, Pimpinelli N, Ficarra G, Borgognoni L, Gaglioti D, Milo D, Romagnoli P (1990) Morphology and membrane antigens of nonlymphoid accessory cells in oral hairy leukoplakia. Hum Pathol 21: 897–904

    Google Scholar 

  112. Rodriguez ER, Nasim S, Hsia J, Sandin RL, Ferreira A, Hilliard BA, Ross AM, Garret CT (1991) Cardiac myocytes and dendritic cells harbor human immunodeficiency virus in infected patients with and without cardiac dysfunction: detection by the polymerase chain reaction in individually microdissected cells from right ventricular endomyocardial biopsy tissue. Am J Cardiol 68: 1511–1520

    Google Scholar 

  113. Roizman B, Sears AE (1987) An inquiry into the mechanisms of herpes simplex virus latency. Annu Rev Microbiol 41: 543–571

    Google Scholar 

  114. Ruby JC, Halliday GM, Muller HK (1989) Differential effects of benzo[a]pyrene and dimethylbenz[a]-anthracene on Langerhans cell distribution and contact sensitization in murine epidermis. J Invest Dermatol 92: 150–157

    Google Scholar 

  115. Ruzicka T, Auböck J (1987) Arachidonic acid metabolism in guinea pig Langerhans cells: studies on cyclooxygenase and lipooxygenase pathways. J Immunol 138: 539–543

    Google Scholar 

  116. Sauder DN, Dinarello CA, Morhen VB (1984) Langerhans cell production of interleukin-1. J Invest Dermatol 82: 605–608

    Google Scholar 

  117. Schmid DS (1988) The human MHC-restricted cellular response to herpes simplex virus type 1 is mediated by CD4+, CD8− T cells and is restricted to the DR region of the MHC complex. J Immunol 140: 3610–3616

    Google Scholar 

  118. Schmitt D, Dezutter-Dambuyant C, Hanau D, Schmitt DA, Kolbe HVJ, Kieny MP, Cazenave JP, Thivolet J (1989) Binding and receptor-mediated endocytosis of HIV glycoproteins by human epidermal Langerhans cells does not require the CD4 HIV binding site. CR Acad Sci 308: 269–275

    Google Scholar 

  119. Schröder S, Schwarz W, Rehpenning W, Löning T, Böcker W (1988) Dendritic/Langerhans cells and prognosis in patients with papillary thyroid carcinoma. Am J Clin Pathol 89: 295–300

    Google Scholar 

  120. Shiohara T, Koyobashi M, Narimatsu H, Nagashima M (1987) Effect of orally administered aromatic retinoid on murine Langerhans cells. Arch Dermatol Res 279: 198–202

    Google Scholar 

  121. Silberberg I, Baer RL, Rosenthal SA (1976) The role of Langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs. J Invest Dermatol 66: 210–217

    Google Scholar 

  122. Simon JC, Cruz PD, Tigelaar RE, Sontheimer RD, Bergstresser PR (1991) Adhesion molecules CD 11a, CD 18 and ICAM-1 on human epidermal Langerhans cells serve a functional role in the activation of alloreactive T cells. J Invest Dermatol 96: 146–151

    Google Scholar 

  123. Simon JC, Krutman J, Elmets CA, Bergstresser PR, Cruz PD (1992) Ultraviolet B irradiated antigen-presenting cells display altered accessory signaling for T-cell activatin. Relevance to immune responses iniated in the skin. J Invest Dermatol 98: 66s-69s

    Google Scholar 

  124. Sinicco A, Palestro G, Caramello P, Giacobbi D, Paggi G, Sciandra M, Gionanni P (1990) Acute HIV-1 infection: clinical and biological study of 12 patients. J Acquir Immune Defic Syndr 3: 260–265

    Google Scholar 

  125. Sornasse T, Flamand V, De Becker G, Bazin H, Tielemans F, Thielemans K, Urbain J, Leo O, Moser M (1992) Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo. J Exp Med 175: 15–21

    Google Scholar 

  126. Sprecher E, Becker Y (1986) Skin Langerhans cells play an essential role in the defense against HSV-1 infection. Arch Virol 91: 341–349

    Google Scholar 

  127. Sprecher E, Becker Y (1987) Herpes simplex virus type 1 pathogenicity in footpad and ear skin of mice depends on Langerhans cell density, mouse genetics and virus strain. J Virol 61: 2515–2522

    Google Scholar 

  128. Sprecher E, Becker Y (1988) Role of epidermal Langerhans cells in viral infections. Arch Virol 103: 1–14

    Google Scholar 

  129. Sprecher E, Becker Y (1989) Langerhans cell number and activity in the skin and lymph nodes determine herpes simplex virus type 1 pathogenicity. Arch Virol 107: 191–205

    Google Scholar 

  130. Sprecher E, Becker Y, Kraal G, Hall E, Harrison D, Shultz LD (1990) Effect of aging on epidermal dendritic cell populations in C 57BL/6J mice. J Invest Dermatol 94: 247–253

    Google Scholar 

  131. Sprecher E, Becker Y (1991) Dendritic cells in the epidermis and the lymph nodes - a review. In: Becker Y (ed) Skin Langerhans (dendritic) cells in virus infections and AIDS. Kluwer Academic Publishers, Boston, pp 3–23

    Google Scholar 

  132. Sprecher E, Becker Y (1991) Involvement of epidermal and lymph node dendritic cells in skin HSV-1 infection, In: Becker Y (ed) Skin Langerhans (dendritic) cells in virus infections and AIDS. Kluwer Academic Publishers, Boston, pp 241–260

    Google Scholar 

  133. Sprecher E, Becker Y (1992) Detection of IL-1β, TNF-α and IL-6 gene transcription by the polymerase chain reaction in keratinocytes, Langerhans cells and peritoneal exudate cells during infection with herpes simplex virus-1. Arch Virol 126: 253–269

    Google Scholar 

  134. Sprecher E,Becker Y (1993) Role of Langerhans cells and other dendritic cells in disease states. In Vivo (in press)

  135. Stein BS, Engleman EG (1991) Mechanism of HIV-1 entry into CD4+ T cells. Adv Exp Med Biol 300: 71–86

    Google Scholar 

  136. Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9: 271–296

    Google Scholar 

  137. Stingl G, Rappersberger K, Tschachler E, Gartner S, Groh V, Mann DL, Wolff K, Popovic M (1990) Langerhans cells in HIV-1 infection. J Am Acad Dermatol 22: 1210–1217

    Google Scholar 

  138. Stössel H, Koch F, Kämpgen E, Stöger P, Lenz A, Heufler C, Romani N, Schuler G (1990) Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells. J Exp Med 172: 1471–1482

    Google Scholar 

  139. Streilein JW, Grammer SF, Yoshikawa T, Demidem A, Vermeer A (1990) Functional dichotomy between Langerhans cells that present antigen to naive and to memory/effector T lymphocytes. Immunol Rev 117: 159–183

    Google Scholar 

  140. Streilein JW (1991) Immunogenetic factors in skin cancer. N Engl J Med 325: 884–887

    Google Scholar 

  141. Stricker RB, Elswood BF, Abrams D (1991) Dendritic cells and dinitrochlorobenzene (DNCB): a new treatment approach to AIDS. Immunol Lett 29: 191–196

    Google Scholar 

  142. Tschachler E, Groh V, Popovic M, Mann DL, Konrad K, Safai B, Eron L, di Marzo Veronese F, Wolff K, Stingl G (1987) Epidermal Langerhans cells - a target for HTLV-III/LAV infection. J Invest Dermatol 88: 233–237

    Google Scholar 

  143. Tsujitani S, Furukawa T, Tamada R, Okamura T, Yasumoto K, Sugimashi K (1987) Langerhans cells and prognosis in patients with gastric carcinoma. Cancer 59: 501–505

    Google Scholar 

  144. Tsujitani S, Okamura T, Baba H, Korenaga D, Haraguchi M, Sugimachi K (1988) Endoscopic intratumoral injection of OK-432 and Langerhans cells in patients with gastric carcinoma. Cancer 61: 1749–1753

    Google Scholar 

  145. Van den Oord JJ, De Vos R, Fachetti F, Delabie J, De Wolf Peeters C, Desmet VJ (1990) Distribution of non-lymphoid, inflammatory cells in chronic HBV infection. J Pathol 160: 223–230

    Google Scholar 

  146. Viac J, Chardonnet Y (1990) Immunocompetent cells and epithelial cell modifications in molluscum contagiosum. J Cutan Pathol 17: 202–205

    Google Scholar 

  147. Viac J, Guerin-Reverchon I, Chardonnet Y, Bremond A (1990) Langerhans cell and epithelial cell modifications in cervical intraepithelial neoplasia: correlation with human papillomavirus infection. Immunobiology 180: 328–338

    Google Scholar 

  148. Vestey JP, Norval M, Howie SEM, Maingay JP, Neill W (1990) Antigen presentation in patients with recrudescent orofacial herpes simplex virus infections. Br J Dermatol 122: 33–42

    Google Scholar 

  149. Wachsman M, Luo JH, Aurelian L, Perkus ME, Paoletti E (1989) Antigen-presenting capacity of epidermal cells infected with vaccinia virus recombinants containing the herpes simplex virus glycoprotein D, and protective immunity. J Gen Virol 70: 2513–2520

    Google Scholar 

  150. Wheeler CE (1988) The herpes simplex problem. J Am Acad Dermatol 18: 163–168

    Google Scholar 

  151. Williams NA, Hill TJ, Hooper DC (1991) Murine epidermal antigen-presenting cells in primary and secondary T-cell proliferative responses to herpes simplex virus in vitro. Immunology 72: 34–39

    Google Scholar 

  152. Williams NA, Hill TJ (1991) Effects on murine epidermal Langerhans cells of drugs known to cause recrudescent herpes simplex virus infection in a mouse model. J Invest Dermatol 97: 933–937

    Google Scholar 

  153. Williams NA, Shimeld C, Hill TJ (1992) The distribution of viral antigens and Langerhans cells during zosteriform spread of herpes simplex virus to the skin of the mouse. Arch Virol 122: 349–358

    Google Scholar 

  154. Yasumoto S, Okabe N, Mori R (1986) Role of epidermal Langerhans cells in resistance to HSV infection. Arch Virol 90: 261–271

    Google Scholar 

  155. Yoshioka A, Miyashi Y, Imamura S, Hiraoka M, Jo S, Abe M (1989) Suppression of contact hypersensitivity by local hyperthermia treatment due to reduced Langerhans cell population in mice. Br J Dermatol 120: 493–501

    Google Scholar 

  156. Zagury D, Bernard G, Leonard R, Cheynier R, Feldman M, Sarin PS, Gallo RC (1986) Long-term cultures of HTLV-III infected T cells: a model of cytopathology of T cell depletion in AIDS. Science 231: 850–853

    Google Scholar 

  157. Zambruno G, Mori L, Marconi A, Mongiardo N, De Rienzo B, Bertazonni U, Gianetti A (1991) Detection of HIV-1 in epidermal Langerhans cells of HIV-infected patients using the polymerase chain reaction. J Invest Dermatol 96: 979–982

    Google Scholar 

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  1. Department of Molecular Virology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

    E. Sprecher & Y. Becker

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Sprecher, E., Becker, Y. Role of Langerhans cells and other dendritic cells in viral diseases. Archives of Virology 132, 1–28 (1993). https://doi.org/10.1007/BF01309840

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