Summary
A rabbit antiserum against the major internal protein, p27, of a psoriasis associated retrovirus-like particle has been used in indirect fluorescence microscopy of biopsies from psoriatic skin. The analysis indicate expression of p27 antigen in epithelial cells in psoriatic lesions and in clinically uninvolved psoriatic skin. A reaction of the antiserum with dermal vessel walls in the lesion was also observed.
This is a preview of subscription content, log in via an institution to check access.
References
Adams, D. S., Crawford, T. B., Klevjer-Anderson, P.: A pathogenic study of the early connective tissue lesions of viral caprine arthritis-encephalitis. Am. J. Pathol.99, 257–278 (1980).
Dalen, A. B., Hellgren, L., Iversen, O.-J., Vincent, J.: A virus-like particle associated with psoriasis. Acta Path. Microbiol. Immunol. Scand.B91, 221–229 (1983).
Georgsson, G., Pálsson, P. A.: The histopathology of Maedi. A slow, viral pneumonia of sheep. Vet. Path.8, 63–80 (1971).
Goodwin, P. G., Hamilton, S., Fry, L.: Comparison between DNA synthesis and mitosis in involved and uninvolved psoriatic epidermis and normal epidermis. Br. J. Dermatol.89, 613–618 (1973).
Guilhou, J. J., Malbos, S., Delalleau, D., Meynadier, J.: Immunofluorescence in psoriasis: Studies of immunoglobulins, complement deposits, and three membrane markers. Arch. Dermatol. Res.271, 295–303 (1981).
Haase, A. T., Stowring, L., Narayan, O., Griffin, D., Price, D.: Slow persistent infection caused by visna virus: Role of host restriction. Science195, 175–177 (1977).
Iversen, O.-J.: Isolation of virus-like particles in urine from a psoriatic patient. Acta Path. Microbiol. Immunol. Scand.B91, 407–412 (1983).
Iversen, O.-J., Dalen, A. B.: Urine proteins cross-reacting with antiserum against virus-like particles from cultured psoriatic epithelial cells. Acta Path. Microbiol. Immunol. Scand.B91, 343–349 (1983).
Iversen, O.-J., Dalen, A. B.: The major internal protein, p 27, of a retrovirus-like particle is expressed in blood lymphocytes from psoriatic patients. Arch. Virol.85, 197–208 (1985).
Iversen, O.-J., Nissen-Meyer, J., Dalen, A.: Characterization of virus-like particles from a psoriatic patient with respect to the possible presence of particle-associated RNA and RNA-directed DNA polymerase. Acta Path. Microbiol. Immunol. Scand.B91, 413–417 (1983).
Iversen, O.-J., Rødahl, E.: The major internal protein, p 27, of a retrovirus-like particle participates in immune complex formation in psoriasis. Arch. Virol.86, 37–46 (1985).
Krogh, H. K., Maeland, J. A., Tønder, O.: Specificity of antigens in aqueous phenol extracts of skin examined by means of guinea pig and rabbit immune sera. Int. Arch. Allergy Appl. Immunol.49, 519, 1975.
Ullman, S., Halberg, P., Hentzer, B.: Deposits of immunoglobulin and complement in psoriatic lesions. J. Cutan. Pathol.7, 271–275 (1980).
van Scott, E. J., Ekel, T. M.: Kinetics of hyperplasia in psoriasis. Arch. Dermatol.88, 373–379 (1963).
Author information
Authors and Affiliations
Additional information
With 3 Figures
Rights and permissions
About this article
Cite this article
Iversen, O.J., Rødahl, E. & Dalen, A.B. Rabbit antibodies against the major internal protein of a retrovirus-like particle bind to epidermal cells in psoriatic skin. Archives of Virology 86, 341–346 (1985). https://doi.org/10.1007/BF01309838
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01309838