Skip to main content
SpringerLink
Log in

Characterization of field isolates of suid herpesvirus 1 (Aujeszky's disease virus) as derivatives of attenuated vaccine strains

  • Original Papers
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

Field isolates of suid herpesvirus 1 (Aujeszky's disease virus) from Poland and Hungary were identified by restriction fragment pattern analysis as derivatives of attenuated vaccine strains. The Polish isolates were found to be related to the BUK-TK-900 strain (Suivac A) which is widely used as a live vaccine in Poland, and the Hungarian isolates were related to the Bartha K-61 vaccine strain widely used in Hungary. Pigs experimentally infected with derivatives of BUK-TK-900 or BUK-TK-900 itself were found to develop gI-antibodies, while pigs infected with derivatives of Bartha K-61 showed a gI-negative response.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Baskerville A, McFerran JB, Dow C (1973) Aujeszky's disease in pigs. Vet Bull 43: 465–480

    Google Scholar 

  2. Bartha A (1961) Experimental reduction of virulence of Aujeszky's disease virus. Magyar Allatorv Lapja 16: 42–45

    Google Scholar 

  3. Beran GW, Davies EB, Arambulo PV, Will LA, Hill HT, Rock DL (1980) Persistence of pseudorabies virus in infected swine. J Am Vet Med Assoc 176: 998–1000

    Google Scholar 

  4. Berns A, van den Ouverland A, Quint W, van Oirschot J, Gielkens AJL (1985) Presence of markers for virulence in the unique short region or repeat region or both of pseudorabies hybrid viruses. J Virol 53: 89–93

    Google Scholar 

  5. Christensen LS, Soerensen KJ, Lei JC (1987) Restriction fragment pattern (RFP) analysis of genomes from Danish isolates of Suid herpesvirus 1 (Aujeszky's disease virus). Arch Virol 97: 215–224

    Google Scholar 

  6. Christensen LS (1988) Comparison by restriction fragment pattern analyses and molecular characterization of some European isolates of Suid herpesvirus 1: a contribution to strain differentiation of European isolates. Arch Virol 102: 39–47

    Google Scholar 

  7. Geck P, Medveczky I, Lomniczi B (1982) Relation of the Bartha's vaccine strain and other avirulent Aujeszky's disease virus strains isolated from field cases. Magyar Allatorv Lapja 37: 657–661

    Google Scholar 

  8. Henderson LM, Levings RL, Davis AJ, Sturtz DR (1991) Recombination of pseudorabies virus vaccine strains in swine. Am J Vet Res 52: 820–825

    Google Scholar 

  9. Kit S (1989) Safety and efficacy of genetically engineered Aujeszky's disease vaccines. In: van Oirschot JT (ed) Vaccination and control of Aujeszky's disease. Curr Top Vet Med Anim Sci 49: 45–56

    Google Scholar 

  10. Kit S (1990) Genetically engineered vaccines for control of Aujeszky's disease. Vaccine 8: 420–424

    Google Scholar 

  11. Lomniczi B, Blankenship ML, Ben-Porat T (1984) Deletions in the genomes of pseudorabies virus vaccine strains and existence of four isomers of the genomes. J Virol 49: 970–979

    Google Scholar 

  12. Lomniczi B, Kaplan AS, Ben-Porat T (1987) Multiple defects in the genome of pseudorabies virus can affect virulence without detectably affecting replication in cell culture. Virology 161: 181–189

    Google Scholar 

  13. Lomniczi B, Nagy E, Kükedi A, Zsák L (1989) Molecular epidemiology of Aujeszky's disease in Hungary. In: van Oirschot JT (ed) Vaccination and control of Aujeszky's disease. Curr Top Vet Med Anim Sci 49: 93–102

    Google Scholar 

  14. Medveczky I, Szabó I (1981) Isolation of Aujeszky's disease virus from boar semen. Acta Vet Acad Hung 29: 29–35

    Google Scholar 

  15. Mengeling WL (1991) Virus reactivation in pigs latently infected with a thymidine kinase negative strain of pseudorabies virus. Arch Virol 120: 57–70

    Google Scholar 

  16. Mettenleiter TC, Lukacs N, Rziha HJ (1985) Pseudorabies virus avirulent strains fail to express a major glycoprotein. J Virol 56: 307–311

    Google Scholar 

  17. Mettenleiter TC, Lomniczi B, Sugg N, Schreurs C, Ben-Porat T (1988) Host cell-specific growth advantage of pseudorabies virus with a deletion in the genome sequences encoding a structural glycoprotein. J Virol 62: 12–19

    Google Scholar 

  18. Van Oirschot JT, Gielkens ALJ, Moormann RJM, Berns AJM (1990) Marker vaccines, virus protein-specific assays and the control of Aujeszky's disease. Vet Microb 23: 85–101

    Google Scholar 

  19. Petrovskis EA, Timmins JG, Armentrout MA, Marchioli CC, Yancey RJ, Post LE (1986) DNA sequence of the gene for pseudorabies virus gp 50, a glycoprotein without N-linked glycosylation. J Virol 59: 216–223

    Google Scholar 

  20. Petrovskis EA, Timmins JG, Gierman TM, Post LE (1986) Deletions in vaccine strains of pseudorabies virus and their effect on synthesis of glycoprotein gp 63. J Virol 60: 1166–1169

    Google Scholar 

  21. Reed LJ, Muench H (1938) A simple method of estimating fifty percent endpoints. Am J Hyg 27: 493–497

    Google Scholar 

  22. Soerensen KJ, Lei JC (1986) Aujeszky's disease: Blocking ELISA for the detection of serum antibodies. J Virol Methods 13: 171–181

    Google Scholar 

  23. Zuckermann FA, Mettenleiter TC, Schreurs C, Sugg N, Ben-Porat T (1988) Complex between glycoproteins gI and gp 63 of pseudorabies virus: its effect on virus replication. J Virol 62: 4622–4626

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State Veterinary Institute for Virus Research, Kalvehave, Denmark

    L. S. Christensen & B. S. Strandbygaard

  2. University of Veterinary Science, Budapest, Hungary

    I. Medveczky

  3. Veterinary Research Institute, Pulawy, Poland

    Z. Pejsak

  4. Institute for Medical Microbiology, University of Copenhagen, Panum Institute Building 24-2, DK-2200, Copenhagen N, Denmark

    L. S. Christensen

Authors
  1. L. S. Christensen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Medveczky
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. S. Strandbygaard
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Z. Pejsak
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Christensen, L.S., Medveczky, I., Strandbygaard, B.S. et al. Characterization of field isolates of suid herpesvirus 1 (Aujeszky's disease virus) as derivatives of attenuated vaccine strains. Archives of Virology 124, 225–234 (1992). https://doi.org/10.1007/BF01309804

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01309804

Keywords

Search

Navigation