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A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains

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Summary

A field isolate of Sendai virus, the Hamamatsu strain, was far more virulent in mice than the prototype Z strain. The Hamamatsu strain replicated more efficiently in the mouse lung than the Z strain, causing deteriorating lung lesions. Nucleotide sequence analysis of the HN, F and M genes revealed that the Hamamatsu strain was divergent from the prototype Z, Harris and Fushimi strains.

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Authors and Affiliations

  1. Department of Bacteriology, Hiroshima University School of Medicine, Kasumi, Minami-ku, Hiroshima, Japan

    T. Sakaguchi, K. Kiyotani, M. Sakaki, Y. Fujii & T. Yoshida

Authors
  1. T. Sakaguchi
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  2. K. Kiyotani
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  3. M. Sakaki
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  4. Y. Fujii
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  5. T. Yoshida
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Additional information

Sequence data from this report have been deposited with the EMBL/DDBJ/GenBank Data Libraries under accession numbers X57213 and D11446.

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Sakaguchi, T., Kiyotani, K., Sakaki, M. et al. A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains. Archives of Virology 135, 159–164 (1994). https://doi.org/10.1007/BF01309773

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  • DOI: https://doi.org/10.1007/BF01309773

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