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Protection against hantavirus infection by dam's immunity transferred vertically to neonates

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  • Published: January 1995
  • Volume 140, pages 165–172, (1995)
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Protection against hantavirus infection by dam's immunity transferred vertically to neonates
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  • K. Dohmae1 &
  • Y. Nishimune1 

  • 120 Accesses

  • 18 Citations

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Summary

Antibodies to hantavirus, Seoul type B-1 strain, vertically transferred to rat neonates prevented lethal as well as persistent infection. When relatively high titer viruses were inoculated into neonates, the mother's antibodies protected all the neonates from lethal virus infection. However, the antibodies could not protect all of the neonates from persistent infection but only half of them underwent persistent infection. The other half was completely cured but also became persistently infected when rechallenged with the active viruses after reaching maturity.

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Authors and Affiliations

  1. Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

    K. Dohmae & Y. Nishimune

Authors
  1. K. Dohmae
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  2. Y. Nishimune
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Cite this article

Dohmae, K., Nishimune, Y. Protection against hantavirus infection by dam's immunity transferred vertically to neonates. Archives of Virology 140, 165–172 (1995). https://doi.org/10.1007/BF01309731

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  • Received: 12 July 1994

  • Accepted: 19 September 1994

  • Issue Date: January 1995

  • DOI: https://doi.org/10.1007/BF01309731

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Keywords

  • Infectious Disease
  • Virus Infection
  • High Titer
  • Titer Virus
  • Persistent Infection
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