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Spontaneous suppressor cell function in inflammatory bowel disease

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Abstract

We investigated suppressor cell activity in the peripheral blood of 39 patients with inflammatory bowel disease (30 Crohn's disease and 9 ulcerative colitis), by the short-lived suppressor cell assay. There was a significant decrease in the suppressor cell activity in patients with inflammatory bowel disease (IBD), compared to 26 healthy subjects studied simultaneously. Five other patients with acute bacterial infections had normal suppressor activity. A group of 14 IBD patients was also investigated, for concanavalin A-induced suppressor cell activity and decreased suppressor function was confirmed. A significant positive correlation was found between the two assays. A defect in suppressor cell activity may permit the expression or maintenance of immunologically mediated damage to the gut in IBD.

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Author notes

  1. Rui M. M. Victorino MD

    Present address: Faculty of Medicine, S. Medicine 2, University Hospital of Santa Maria, 1699, Lisbon, Portugal

Authors and Affiliations

  1. Gastroenterology Unit, Department of Medicine, Royal Postgraduate Medical School, W12 OHS, London, UK

    Rui M. M. Victorino MD &  Humphrey J. F. Hodgson MRCP

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  1. Rui M. M. Victorino MD
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  2. Humphrey J. F. Hodgson MRCP
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Work supported in part by a grant from the Medical Research Council (United Kingdom).

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Victorino, R.M.M., Hodgson, H.J.F. Spontaneous suppressor cell function in inflammatory bowel disease. Digest Dis Sci 26, 801–806 (1981). https://doi.org/10.1007/BF01309612

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