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Digestive Diseases and Sciences

, Volume 26, Issue 10, pp 865–870 | Cite as

Zinc nutrition in Crohn's disease

  • C. Richard Fleming
  • Kenneth A. Huizenga
  • John T. McCall
  • Jeanne Gildea
  • Rodney Dennis
Original Articles

Abstract

A prospective evaluation of zinc status was made in 63 randomly selected patients with Crohn's disease. In the patients, mean serum and 24-hr urinary zinc values-105 μg/dl and 383 μg/day, respectively—were not different from controls. However, 46% of these patients had less than normal serum zinc and 36% had low urinary zinc excretions. Simultaneous reductions in both serum and urinary zinc were detected in 19% of patients. A direct correlation (P=0.01) was found between serum levels of zinc and the concentration of albumin, the major zinc-binding protein, in outpatients but not in hospitalized patients or patients with Crohn's disease as a whole. Intake of zinc was surprisingly good—a mean intake of 13.4±1.4 mg/day. A significant (P=0.006) association was found between urinary zinc and the Crohn's disease activity index but not between serum zinc concentration and this index. No association was found between zinc measurements and the presence or absence of fistulas, use of prednisone or sulfasalazine (Azulfidine), large bowel resections, and length of small bowel resected.

Keywords

Zinc Zinc Concentration Sulfasalazine Bowel Resection Disease Activity Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Solomons NW, Rosenberg IH, Sandstead HH, Vo-Khactu KP: Zinc deficiency in Crohn's disease. Digestion 16:87–95, 1977Google Scholar
  2. 2.
    McClain C, Soutor C, Zieve L: Zinc deficiency: A complication of Crohn's disease. Gastroenterology 78:272–279, 1980Google Scholar
  3. 3.
    Mills PR, Fell GS: Zinc and inflammatory bowel disease. Am J Clin Nutr 32:2172–2173, 1979 (letter to the editor)Google Scholar
  4. 4.
    Dronfield MW, Malone JDG, Langman MJS: Zinc in ulcerative colitis: A therapeutic trial and report on plasma levels. Gut 18:33–36, 1977Google Scholar
  5. 5.
    Analytical Methods for Atomic Absorption Spectrophotometry. Norwalk, Connecticut, Perkin-Elmer Corporation, 1973Google Scholar
  6. 6.
    Sturniolo GC, Mastropaolo G, Naccarato R: Zinc concentrations. Gastroenterology 79:185–186, 1980 (letter to the editor)Google Scholar
  7. 7.
    Best WR, Becktel JM, Singleton JW, Kern F Jr: Development of a Crohn's Disease Study. Gastroenterology 70:439–444, 1976Google Scholar
  8. 8.
    Haeflein KA, Rasmussen AI: Zinc content of selected foods. J Am Diet Assoc 70:610–616, 1977Google Scholar
  9. 9.
    Murphy EW, Willis BW, Watt BK: Provisional tables on the zinc content of foods. J Am Diet Assoc 66:345–355, 1975Google Scholar
  10. 10.
    Pekarek RS, Wannemacher RW Jr, Beisel WR: The effect of leukocytic endogenous mediator (LEM) on the tissue distribution of zinc and iron. Proc Soc Exp Biol Med 140:685–688, 1972Google Scholar
  11. 11.
    Falchuk KH: Effect of acute disease and ACTH on serum zinc proteins. N Engl J Med 296:1129–1134, 1977Google Scholar
  12. 12.
    Pekarek RS: Commission on Epidemiological Survey Annual Report FY 1971, 1971, p 99Google Scholar
  13. 13.
    Solomons NW, Elson CO, Pekarek RS, Jacob RA, Sandstead HH, Rosenberg IH: Leukocytic endogenous mediator in Crohn's disease. Infect Immun 22:637–639, 1978Google Scholar
  14. 14.
    Solomons NW: On the assessment of zinc and copper nutriture in man. Am J Clin Nutr 32:856–871, 1979Google Scholar
  15. 15.
    Sturniolo GC, Molokhia MM, Shields R, Turnberg, LA: Zinc absorption in Crohn's disease. Gut 21:387–391, 1980.Google Scholar
  16. 16.
    Wolman SL, Anderson GH, Marliss EB, Jeejeebhoy KN: Zinc in total parenteral nutrition: Requirements and metabolic effects. Gastroenterology 76:458–467, 1979Google Scholar
  17. 17.
    Kay RG, Tasman-Jones C, Pybus J, Whiting R, Black H: A syndrome of acute zinc deficiency during total parenteral alimentation in man. Ann Surg 183:331–340, 1976Google Scholar
  18. 18.
    Fleming CR, Hodges RE, Hurley LS: A prospective study of serum copper and zinc levels in patients receiving total parenteral nutrition. Am J Clin Nutr 29:70–77, 1976.Google Scholar
  19. 19.
    Flynn A, Pories WJ, Strain WH, Hill OA Jr, Fratianne RB: Rapid serum-zinc depletion associated with corticosteroid therapy. Lancet 2:1169–1171, 1971Google Scholar
  20. 20.
    Henkin RI, Meret S, Jacobs JB: Steroid-dependent changes in copper and zinc metabolism. J Clin Invest 48:38a, 1969 (abstract)Google Scholar
  21. 21.
    Briggs MH, Briggs M, Austin J: Effects of steroid pharmaceuticals on plasma zinc. Nature 232:480–481, 1971Google Scholar
  22. 22.
    Truelove SC, Witts LJ: Cortisone in ulcerative colitis: Final report on a therapeutic trial. Br Med J 2:1041–1048, 1955Google Scholar

Copyright information

© Digestive Disease Systems, Inc. 1981

Authors and Affiliations

  • C. Richard Fleming
    • 1
    • 2
  • Kenneth A. Huizenga
    • 1
    • 2
  • John T. McCall
    • 1
    • 2
  • Jeanne Gildea
    • 1
    • 2
  • Rodney Dennis
    • 1
    • 2
  1. 1.Division of Gastroenterology and Internal MedicineMayo Clinic and Mayo FoundationRochester
  2. 2.Department of Laboratory MedicineMayo Clinic and Mayo FoundationRochester

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