Abstract
Misoprostol, a PGE1 derivative that inhibits gastric acid secretion in rats, was compared with cimetidine and sucralfate in several rat experimental ulcer models. Gastric lesions were produced by aspirin, indomethacin, stress, sodium taurocholate, and ethanol. In all tests, misoprostol (50, 100, and 200 μg/kg) and cimetidine and sucralfate (50, 100, and 200 mg/kg) were administered intragastrically. Misoprostol protected against gastric lesions in all five experimental ulcer models at lower than gastric antisecretory doses. Cimetidine protected in the indomethacin, aspirin, and stress models, but only at gastric antisecretory doses, and did not protect against lesion formation in the ethanol and taurocholate models. Sucralfate, over the dose range tested, was not consistently protective in any of the five experimental ulcer models. It is concluded that misoprostol provides gastric mucosal protection against a wide variety of noxious agents by means of a unique mechanism and that reduction of gastric acid secretion is not required, as it is with cimetidine, for the protective effect.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Robert A: Prostaglandins and the gastrointestinal tract.In Physiology of the Gastrointestinal Tract. LD Johnson (ed). New York. Raven Press, 1981, pp 1407–1434
Miller TA: Protective effects of prostaglandins against gastric mucosal damage: Current knowledge and proposed mechanisms. Am J Physiol 245:G601-G623, 1983
Dajani EZ, Driskill DR, Bianchi RG, Collins PW, Pappo R: SC-29333: A potent inhibitor of canine gastric secretion. Dig Dis Sci 21:1049–1057, 1976
Bianchi RG, Dajani EZ, Casler JJ: Gastric antisecretory and antiulcer activity of SC-29333: A synthetic E-prostaglandin analog. Pharmacologist 23:121, 1981 (abstract)
Brodie DA, Chase BJ: Role of gastric acid in aspirin-induced gastric irritation in the rat. Gastroenterology 53:604–610, 1967
Lipmann W: Inhibition of indomethacin-induced gastric ulceration in the rat by perorally administered synthetic and natural prostaglandin analogs. Prostaglandins 7:1–10, 1974
Carmichael HA, Nelson L, Ruseel RI, Lyon A, Chandra V: The effect of synthetic prostaglandin analog 15(R)-methyl PGE2 methyl ester on gastric mucosal hemorrhage induced in rats by taurocholate acid and hydrochloride acid. Am J Dig Dis 22:411–414, 1977
Robert A, Nezamis JE, Lancaster C, Hanchar AJ: Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 77:433–443, 1979
Robert A, Northam JI, Nezamis JE, Phillips JP: Exertion ulcers in the rat. Am J Dig Dis 15:497–507, 1970
Nagashima R, Hoshino E, Hinohara Y, Sakai K, Hata S, Nakano H: Effect of sucralfate on ethanol-induced gastric mucosal damage in the rat. Scand J Gastroenterol 18(Suppl 83): 17–20, 1983
Hollander D, Tarnawski A, Gergely H, Zipser RD: Sucralfate protection of the gastric mucosa against ethanol-induced injury: A prostaglandin-mediated process? Scand J Gastroenterol 19(Suppl 101):97–102, 1984
Robert A, Lancaster C, Davis JP, Field SO, Nezamis JE: Distinction between antiulcer effect and cytoprotection. Scand J Gastroenterol 19:69–72, 1984
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bauer, R.F., Bianchi, R.G., Casler, J. et al. Comparative mucosal protective properties of misoprostol, cimetidine, and sucralfate. Digest Dis Sci 31 (Suppl 2), 81S–85S (1986). https://doi.org/10.1007/BF01309328
Issue Date:
DOI: https://doi.org/10.1007/BF01309328