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Relationship between tissue calcium content and duodenal ulcer in the rat

Digestive Diseases and Sciences volume 38, pages 1468–1472 (1993)Cite this article

Abstract

Since the effect of cellular calcium on cell injury has been in question, this study focused on the relationship between tissue calcium content and cysteamine-induced duodenal ulcer. Rats treated with cysteamine showed a high frequency and severity of duodenal ulcer, and the calcium content in the duodenal mucosa was elevated. Furthermore, the level of calcium content in duodenal mucosa was positively associated with the severity of the duodenal lesion. Whereas administration of calcium increased duodenal ulcerative response to cysteamine, verapamil afforded protection against ulceration. We conclude that calcium accumulation in duodenal mucosa is related to duodenal ulceration induced by cysteamine.

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Affiliations

  1. Department of Pathology, LSU Medical Center, New Orleans, Louisiana

    Zhiwei Zhang MD, Guozhen Chen MD, Shiqiang Liu MD & Shizhen Yuang MD

  2. Division of Gastroenterology, Sun Yat-Sen Memorial Hospital, Guangzhou, People's Republic of China

    Zhiwei Zhang MD, Guozhen Chen MD, Shiqiang Liu MD & Shizhen Yuang MD

Authors
  1. Zhiwei Zhang MD
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  2. Guozhen Chen MD
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  3. Shiqiang Liu MD
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  4. Shizhen Yuang MD
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Zhang, Z., Chen, G., Liu, S. et al. Relationship between tissue calcium content and duodenal ulcer in the rat. Digest Dis Sci 38, 1468–1472 (1993). https://doi.org/10.1007/BF01308605

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  • DOI: https://doi.org/10.1007/BF01308605

Key Words

  • duodenal ulcer
  • tissue calcium
  • cysteamine
  • verapamil