Abstract
While total parenteral nutrition is widely used, its effects on gastrointestinal function are not well understood. We measured acid secretion in 11 patients during total parenteral nutrition. Five of these patients were retested at least one month after resuming oral intake. Total parenteral nutrition significantly stimulated acid secretion compared to saline infusion (5.5±2.0 vs 1.8±0.6 mEq H+/hr,P<0.001) (mean±sem), especially in those patients who are hypersecretors. There was no difference in pentagastrin-stimulated maximal acid output during TPN or saline infusion. Basal and pentagastrin-stimulated acid secretion were similar during and after a course of total parenteral nutrition, suggesting that gastric atrophy did not occur during total parenteral nutrition therapy.
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Supported by grants from the National Foudation for Ileitis and Colitis, Veterans Administration Career Development Program [Dr. Levine, (RA 1009)] and McGaw Laboratories.
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Levine, G.M., Mullen, J.L. & O'Neill, F. Effect of total parenteral nutrition on gastric acid secretion. Digest Dis Sci 25, 284–288 (1980). https://doi.org/10.1007/BF01308519
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DOI: https://doi.org/10.1007/BF01308519