Skip to main content
Log in

An update on histamine receptors and the gastrointestinal tract

  • Review Article
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Black JW, Duncan WAM, Durant CJ, Ganellin CR, Parsons EM: Definition and antagonism of histamine H2 receptors. Nature 236:385–389, 1972

    Google Scholar 

  2. Hirschowitz BI: H2 histamine receptors. Annu Rev Pharmacol Toxicol 19:203–244, 1979

    Google Scholar 

  3. Hirschowitz BI, Hutchison G: Gastric H+ and pepsin secretion in fistula dogs with histamine, betazole, triazole andN-methyl histamines. Am J Physiol 226:656–661, 1974

    Google Scholar 

  4. Code CF: Reflections on histamine, gastric secretion and the H2 receptor. N Engl J Med 296:1459–1462, 1977

    Google Scholar 

  5. Durant GJ, Ganellin CR, Parsons ME: Dimaprit, [S-[3-N,N-dimethylamino)propyl]isothiourea]. A highly specific histamine H2 receptor agonist. 2. Structure-activity considerations. Agents Actions 7:39–43, 1977

    Google Scholar 

  6. Hirschowitz B, Rentz J, Molina E: Gastric and cardiac H-2 receptor effects of dimaprit andN′(Me),5(Me)histamine in conscious dogs. Eur J Pharmacol 61(4):355–361, 1980

    Google Scholar 

  7. Molina E, Hirschowitz B: Use of impromidine to define specific histamine H-2 effects on gastric secretion, heart rate and blood pressure in conscious dogs. J Pharmacol Exp Ther 214(3):483–487, 1980

    Google Scholar 

  8. Hunt RH, Mills JG, Beresford J, Billings JA, Burland WL, Milton-Thompson GJ: Gastric secretory studies in humans with impromidine (SKF 92676)—a specific histamine H2 receptor agonist. Gastroenterology 78(3):505–511, 1980

    Google Scholar 

  9. Parsons M, Sykes C: Impromidine (SKF 92676) acts as a partial agonist on the isolated whole stomach of the rat. Br J Pharmacol 69(1):6–7, 1980

    Google Scholar 

  10. Hersey SJ: Histamine receptors in bullfrog gastric mucosa. Am J Physiol 241(2):G93–97, 1981

    Google Scholar 

  11. Parsons ME, Owen DAA, Ganellin CR, Durant GJ: Dimaprit-[S[3-(N,N-dimethylamino)propyl] i-sothiourea]—a highly specific histamine H2-receptor agonist. 1. Pharmacology. Agents Actions 7:31–37, 1977

    Google Scholar 

  12. Impicciatore M, Bertaccini G, Mosini F, Hansen DO, Grossman MI:N-Methyl, 5-methyl histamine evokes a higher maximal rate of gastric acid secretion than histamine. Proc Soc Exp Biol Med 156:296–298, 1977

    Google Scholar 

  13. Curwain BP, Turner NC: The involvement of histamine receptor subtypes in gastric acid secretion and mucosal blood flow in the anesthetized rabbit. J Physiol (London) 311:431–442, 1981

    Google Scholar 

  14. Soll AH: Physiology of isolated canine parietal cells: Receptors and effectors regulating function.In Physiology of the Digestive Tract. LR Johnson (ed). New York, Raven Press, 1981, pp 673–691

    Google Scholar 

  15. Bearer CF, Chang LK, Rosenfeld GC, Thompson WJ: Histamine stimulation of rat gastric parietal cell adenyl-cyclase: Modulation by guanine nucleotides. Arch Biochem Biophys 207(2):325–336, 1981

    Google Scholar 

  16. Mihas A, Gibson RG, Hirschowitz BI: Inhibition of gastric secretion in the dog by 16,16-dimethyl prostaglandin E2. Am J Physiol 230:351–356, 1976

    Google Scholar 

  17. Helander HF, Hirschowitz BI: Quantitative ultrastructural studies on inhibited and on partly stimulated gastric parietal cells. Gastroenterology 67:447–452, 1974

    Google Scholar 

  18. Carlisle KS, Chew CS, Hersey SJ: Ultrastructural changes and cyclic AMP in frog oxyntic cells. J Cell Biol 76:31–42, 1978

    Google Scholar 

  19. Hirschowitz BI, Sachs G, Hutchison G: Lack of potentiation or synergism between histamine and pentagastrin in the fistula dog. Am J Physiol 224:509–513, 1973

    Google Scholar 

  20. Hirschowitz BI, Molina E: Effect of cimetidine on histamine-stimulated gastric acid and electrolytes in dogs. Am J Physiol 244:G416-G420, 1983

    Google Scholar 

  21. Hirschowitz BI, Molina E: Effects of four H2 histamine antagonists on bethanechol-stimulated acid and pepsin secretion in the dog. J Pharmacol Exp Ther 224:341–345, 1983

    Google Scholar 

  22. Hirschowitz BI, Hutchison GA: Evidence for a histamine H2 receptor that inhibits pepsin secretion in the dog. Am J Physiol 2:E225–228, 1977

    Google Scholar 

  23. Hirschowitz BI, Rentz J, Molina E: Histamine H2 receptors stimulation and inhibition of pepsin secretion in the dog. J Pharmacol Exp Ther 218(3):676–680, 1981

    Google Scholar 

  24. Burhol PG: A review: Regulation of gastric secretion in the chicken. Scand J Gastroenterol 17:321–323, 1982

    Google Scholar 

  25. Simpson L, Goldenberg D, Hirschowitz BI: Pepsinogen secretion by the frog esophagusin vitro. Am J Physiol 238:G79–84, 1980

    Google Scholar 

  26. Burland WL, Mills JG, Sharpe PC, Horton MA, Mollin DL: The effect of cimetidine on intrinsic factor secretion.In Cimetidine: 2nd International Symposium. Histamine H2 Receptor Antagonists. WL Burland, MA Simkins (eds). Amsterdam, Excerpta Medica, 1977, 392 pp

    Google Scholar 

  27. Fielding LP, Chalmers DM, Canavin I, Levi AJ: Inhibition of intrinsic factor secretion by cimetidine. Lancet 1:818–819, 1978

    Google Scholar 

  28. Barbezat GO, Daniel M, Bank S, Grant B, Vinik A: The effect of histamine H2-receptor blockade on fasting serum gastrin and fasting gastric acid secretion in the dog. Nature 249:666–668, 1975

    Google Scholar 

  29. Hirschowitz BI, Danilewitz M, Molina E: Inhibition of basal acid, chloride and pepsin secretion in duodenal ulcer by graded doses of ranitidine and atropine with studies of pharmacokinetics of ranitidine. Gastroenterology 82:1314–1326, 1982

    Google Scholar 

  30. Carter DC, Forrest JAH, Logan RA, Ansell I, Lidgard G, Heading RC, Shearman DJC: Effect of histamine H2-receptor antagonist, cimetidine, on gastric secretion and serum gastrin during insulin infusion in man. Scand J Gastroenterol 11:565–570, 1976

    Google Scholar 

  31. Pounder RE, Hunt RH, Vincent SH, Milton Thompson GJ, Misiewicz JJ: 24-Hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer during oral administration of cimetidine and atropine. Gut 18:85–90, 1977

    Google Scholar 

  32. Bank S, Barbezat GO, Vinik AI, Helman C: Serum gastrin levels before and after 6 weeks of cimetidine therapy in patients with duodenal ulcer. Digestion 15:157–161, 1977

    Google Scholar 

  33. Richardson CT, Bailey BA, Walsh JH, Fordtran JS: The effect of an H2-receptor antagonist of food-stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcers. Comparison with an anticholinergic drug. J Clin Invest 55:536–542, 1975

    Google Scholar 

  34. Longstreth GF, Go VLW, Malagelada JR: Postprandial gastric, pancreatic, and biliary response to histamine H2 receptor antagonists in active duodenal ulcer. Gastroenterology 72:9–13, 1977

    Google Scholar 

  35. Nishibori M: Cyclic AMP increase in canine parotid gland mediated by histamine H2-receptors. Eur J Pharmacol 76(4):309–316, 1981

    Google Scholar 

  36. Guth PH, Smith E: The effect of gastrointestinal hormones on the gastric microcirculation. Gastroenterology 71:435–438, 1976

    Google Scholar 

  37. Main IHM, Whittle BJR: A study of the vascular and acid-secretory responses of the rat gastric mucosa to histamine. J Physiol (London) 257:407–418, 1976

    Google Scholar 

  38. Flynn SB, Johnston BM, Owen DAA: The cardiovascular response to dimaprit, a selective histamine H2-receptor agonist. Br J Pharmacol 61:101–107, 1977

    Google Scholar 

  39. Johnston BM, Owen DAA: Tissue blood flow and distribution of cardiac output in cats: Changes caused by intravenous infusions of histamine and histamine receptor agonists. Br J Pharmacol 60:173–180, 1977

    Google Scholar 

  40. Curwain BP, Turner NC: Histamine H1 and H2 receptors in the gastric vasculature of the rabbit. Eur J Pharmacol 71(4):515–519, 1981

    Google Scholar 

  41. Gerger JG, Nies AS: Canine gastric mucosal vasodilation with prostaglandins and histamine analogs. Dig Dis Sci 27(10):870–874, 1982

    Google Scholar 

  42. Gerkens JG, Flexner C, Oates JA, Shand DG: Prostaglandin and histamine involvement in the gastric vasodilator action of pentagastrin. J Pharmacol Exp Ther 201:421–426, 1977

    Google Scholar 

  43. Mortillaro NA, Granger DN, Kvietys PR, et al: Effects of histamine and histamine antagonists on intestinal capillary permeability. Am J Physiol 240(5):G381–386, 1981

    Google Scholar 

  44. Walus KM, Fondacara JD, Jacobson ED: Mesenteric vascular reactivity to histamine receptor agonists and antagonists. Dig Dis Sci 26(5):438–443, 1981

    Google Scholar 

  45. Richardson PDI, Withrington PG: A comparison of the effects of bradykinin, 5-hydroxytryptamine, and histamine on the hepatic arterial and portal venous vascular beds of the dog: Histamine H1 and H2-receptor populations. Br J Pharmacol 60:123–133, 1977

    Google Scholar 

  46. Nakazawa S, Ichikawa T, Naito Y, Tsukamoto Y: Effect of histamine on the gastric smooth muscles of guinea pig. Digestion 22(4):203–209, 1981

    Google Scholar 

  47. Ercan AX, Turker RK: Histamine receptors in the isolated rat stomach fundus and rabbit aortic strips. Pharmacology 15:118–126, 1977

    Google Scholar 

  48. Heading RC, Logan RFA, McLoughlin GP, Lidgard G, Forrest JAH: Effect of cimetidine on gastric emptying.In Cimetidine: 2nd International Symposium Histamine H-2 Receptor Antagonists. WL Burland, MA Simkins (eds). Amsterdam, Excerpta Medica, 1977, pp 145–154

    Google Scholar 

  49. Biancani P, Cicalzi LK, McCallum RW: Mechanism of histamine-induced excitation of the cat pylorus. J Clin Invest 68(3):582–588, 1981

    Google Scholar 

  50. Ash ASF, Schild HO: Receptors mediating some actions of histamine. Br J Pharmacol 27:427–439, 1966

    Google Scholar 

  51. Brimblecombe RW, Duncan WAM: The relevance to man of preclinical data for cimetidine.In Cimetidine: 2nd International Symposium Histamine H-2 Receptor Antagonists. WL Burland, MA Simkins (eds). Amsterdam, Excerpta Medica, 1977, pp 54–65

    Google Scholar 

  52. Botting JH: Sensitivity of neonatal rabbit ileum to histamine. Br J Pharmacol 53:428–429, 1975

    Google Scholar 

  53. Konturek SJ, Siebers R: Role of histamine H and H2 receptors on myoelectric activity of small bowel in the dog. Am J Physiol 238(1):G50–56, 1980

    Google Scholar 

  54. Barker LA, Ebersole BJ: Histamine H2-receptors on guinea pig ileum myenteric plexus neurons mediate the release of contractile agents. J Pharmacol Exp Ther 221(1):69–75, 1982

    Google Scholar 

  55. Waldman DB, Zfass AM, Makhlouf GM: Stimulatory (H1) and inhibitory (H2) histamine receptors in gallbladder muscle. Gastroenterology 72:932–936, 1977

    Google Scholar 

  56. Schoetz DJ Jr, Wise WE Jr, La Morte WW, et al: Histamine receptors in primate gallbladder. Dig Dis Sci 28(4):353–358, 1983

    Google Scholar 

  57. Freston JW: Cimetidine. I. Developments, pharmacology, and efficacy. II. Adverse reactions and pattern of use. Ann Intern Med 97(4):573–580; 728–734, 1982

    Google Scholar 

  58. Brogden RN, Carmine A, Heel RC, et al: Ranitidine: A review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases. Drugs 24:267–303, 1982

    Google Scholar 

  59. Burland WL, Simkins MA (eds): 1977. Cimetidine: 2nd International Symposium on Histamine H2 Receptor Antagonists. Amsterdam, Excerpta Medica, 392 pp

    Google Scholar 

  60. Burland WL, Sharpe PC, ColinJones DG, Turnbull PRG, Bowskill P: Reversal of metiamide-induced agranulocytosis during treatment with cimetidine. Lancet 2:1085, 1975

    Google Scholar 

  61. Feldman EJ, Isenberg JI: Effects of metiamide on gastric acid hypersecretion, steatorrhea and bone marrow function in a patient with systemic mastocytosis. N Engl J Med 295:1178–1179, 1976

    Google Scholar 

  62. Fleischer D, Samloff IM: Cimetidine therapy in a patients with metiamide-induced agranulocytosis. N Engl J Med 296:342, 1977 (letter)

    Google Scholar 

  63. Hirschowitz BI: Controls of gastric secretion: A roadmap to the choice of treatment for duodenal ulcer. Am J Gastroenterol 77:281–293, 1982

    Google Scholar 

  64. Hirschowitz BI: Natural history of duodenal ulcer. Gastroenterology 85(4):967–970, 1983

    Google Scholar 

  65. Hirschowitz BI: Gastric ulcer.In Current Therapy in Gastroenterology and Liver Disease. TM Bayless (ed). New York, BC Decker, 1983, Chap 14

    Google Scholar 

  66. Taylor RH, Lovell D, MenziesGow N, LaBrooy SJ, Misiewicz JJ: Misleading response of malignant gastric ulcers to cimetidine. Lancet 1:686–688, 1978

    Google Scholar 

  67. Machell RJ, Ciclitira PJ, Farthing MJG, Rose JDR, Dick AD, Hunter JO: Maintenance cimetidine in the prevention of gastric ulcer relapse. Ann Br Soc Gastroenterol Abstr FA43, 1978

  68. Jensen R, Pandol SJ, Martin JC, et al: Diagnosis and management of the Zollinger-Ellison syndrome. J Clin Gastroenterol 5(Suppl. 1):123–131, 1983

    Google Scholar 

  69. Richardson CT, Feldman M, McClelland RN, et al: Effect of vagotomy in Zollinger-Ellison syndrome. Gastroenterology 77:682–686, 1979

    Google Scholar 

  70. Danilewitz M, Ou Tim L, Hirschowitz B: Ranitidine suppression of gastric hypersecretion resistant to cimetidine. N Engl J Med 316:20–22, 1982

    Google Scholar 

  71. Behar J, Brand DL, Brown FC, Castell DO, Cohen S, Crossley RJ, Pope CE II, Winans CS: Cimetidine in the treatment of symptomatic gastroesophageal reflux. A double-blind controlled trial. Gastroenterology 74:441–448, 1978

    Google Scholar 

  72. Nishibori M: Cyclic AMP increase in canine parotid gland mediated by histamine H2-receptors. Eur J Pharmacol 76:309–316, 1981

    Google Scholar 

  73. Cooke MJ, Nemeth PR, Wood D: Histamine action on guinea pig ileal mucosa. Am J Physiol 246(4P+1):G372–377, 1984

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hirschowitz, B.I. An update on histamine receptors and the gastrointestinal tract. Digest Dis Sci 30, 998–1004 (1985). https://doi.org/10.1007/BF01308297

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01308297

Keywords

Navigation