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Tissue-type plasminogen activator of colonic mucosa in ulcerative colitis

Evidence of endothelium-derived fibrinolytic activation

Digestive Diseases and Sciences volume 37, pages 307–311 (1992)Cite this article

Abstract

Microvascular endothelial alterations are thought to be a crucial step for development of hemorrhagic changes in various pathological states. In this study, we determined the activity and amount of tissue-type plasminogen activator (t-PA) in the biopsy specimens from sigmoid colon of patients with ulcerative colitis to evaluate endothelial alterations and vascular changes of permeability. The results of this investigation revealed that mucosal amount of t-PA in the active stage of ulcerative colitis was two- to threefold higher than in healthy controls, while t-PA levels in plasma samples showed no remarkable differences among the groups. Increased t-PA activity appeared to correlate well to the degree of inflammation of colonic mucosa, and t-PA amount was still increased in the inactive stage. The present study indicates that t-PA determination in colonic biopsy specimens may be useful for the evaluation of clinical activity of ulcerative colitis in terms of the mucosal microvascular endothelial changes.

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Affiliations

  1. Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160, Tokyo, Japan

    Iwao Kurose, Soichiro Miura, Makoto Suematsu, Hiroshi Serizawa, Dai Fukumura, Hiroshi Asako, Toshifumi Hibi &  Masaharu Tsuchiya

Authors
  1. Iwao Kurose
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  2. Soichiro Miura
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  3. Makoto Suematsu
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  4. Hiroshi Serizawa
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  5. Dai Fukumura
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  6. Hiroshi Asako
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  7. Toshifumi Hibi
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  8. Masaharu Tsuchiya
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Additional information

This work was supported by the grant from the Japanese Ministry of Education No. 63440033 and by the grant from Keio University, School of Medicine.

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Kurose, I., Miura, S., Suematsu, M. et al. Tissue-type plasminogen activator of colonic mucosa in ulcerative colitis. Digest Dis Sci 37, 307–311 (1992). https://doi.org/10.1007/BF01308189

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  • DOI: https://doi.org/10.1007/BF01308189

Key Words

  • ulcerative colitis
  • tissue-type plasminogen activator
  • plasminogen activator inhibitor-1
  • endothelial cell
  • fibrinolysis