Abstract
Twenty patients with the ascites of chronic liver disease were investigated for in vivo evidence of active coagulation within ascites by detection of fibrin monomer. Increased levels of fibrin monomer, increased fibrin/fibrinogen degradation products, and absent or low levels of fibrinogen in the ascites of all patients tested confirmed the presence of intraperitoneal coagulation when ascites is present.
Similar content being viewed by others
References
Phillips LL, Rodgers JB: Procoagulant activity of ascitic fluid in hepatic cirrhosis:In vivo andin vitro. Surgery 86(5):714–721, 1979
Harmon DC, Demirjian Z, Ellman L, Fischer JE: Disseminated intravascular coagulation with the peritoneovenous shunt. Ann Intern Med 90(5):744–776, 1979
Lerner RG, Nelson JC, Corines P, del Guercio LRM: Disseminated intravascular coagulation. J Am Med Assoc 240(19):2064–2066, 1978
Ansley JD, Bethel RA, Bowen PA III, Warren WD: Effect of peritoneovenous shunting with the LeVeen valve on ascites, renal function, and coagulation in six patients with intractable ascites. Surgery 83(2):181–187, 1978
Schwartz ML, Swaim WR, Vogel SB: Coagulopathy following peritoneovenous shunting. Surgery 85(6):671–676, 1979
Blendis LM, Greig PD, Langer B, Baigrie RS, Ruse J, Taylor BR: The renal and hemodynamic effects of the peritoneovenous shunt for intractable hepatic ascites. Gastroenterology 77:250–257, 1979
Wilkinson SP, Henderson J, Davidson AR, Williams R: Ascites reinfusion using the Rhodiascit apparatus—clinical experience and coagulation abnormalities. Postgrad Med J 51:583–587, 1975
Villeneuve JP, Thout C, Marleau D, Joly JG, Huet PM, Viallet A: Treatment of resistant ascites by continuous ultrafiltration-reinfusion of ascitic fluid. Can Med Assoc J 117:1297–1298 1977
Benz JJ: Clotting factors and fibrinogen split products in the extravascular space. Thromb Diath Haemorrh 20:226–235, 1968
Henderson JM, Stein S, Chawla RK, Rudman D: The protein content of ascitic fluid. Gastroenterology 77(5):A16, 1979
Svanberg L, Astedt B: Coagulative and fibrinolytic properties of ascitic fluid associated with ovarian tumors. Cancer 35:1382–1387, 1975
Denny GP, Minot GP: The coagulation of blood in the pleural cavity. Am J Physiol 39:455–458, 1916
Clauss A: Gerinnungsphysiologische Schnell Methode zur Bestimmung des Fibrinogens. Acta Haematol (Basel) 17:237, 1957
Ratky SM, Martin MJ, Gordon YB, Baker LRI, Leslie J, Chard T: A comparison between radioimmunoassay and other immunological techniques for the measurement of fibrinogen/fibrin degradation products in serum. Br J Haematol 30:145–149, 1975
Arocha-Pinango CL: A comparison of the TRC II and Latexparticle tests for titration of FR-antigen. J Clin Pathol 25:757–761, 1972
Gurewich V, Hutchinson E: Detection of intravascular coagulation by a serial-dilution protamine sulfate test. Ann Intern Med 75:895–902, 1971
Niewiardowski S, Gurewich V: Laboratory identification of intravascular coagulation. J Lab Clin Med 77:665–676, 1971
Quismorio FP Jr, Kaufman RC, Halle P, Hoefs JC: Immune complexes and cryoproteins in ascitic fluid of patients with alcoholic liver disease. Int Arch Allergy Appl Immunol 64:190–194, 1981
Roberts HR, Cederbaum AI: The liver and blood coagulation: Physiology and pathophysiology. Gastroenterology 63:297–320, 1972
Walls WD, Losowsky MS: The hemostatic defect of liver disease. Gastroenterology 60:108–119, 1971
Veltkamp JJ, Kreuning J: The diagnostic value of coagulation studies in chronic liver disease. Scand J Gastroenterol 8(Suppl 19):93–95, 1973
Koller F: Theory and experience behind the use of coagulation tests in diagnosis and prognosis of liver disease. Scand J Gastroenterol 8(Suppl 19):51–61, 1973
Bloom AL: Intravascular coagulation and the liver. Br J Haematol 30:1–7, 1975
Johnson CA, Sobrinho TCM, Axiz EM, Rogers SB: Refractory coagulopathy in an infant with loss of clotting proteins into ascitic fluid. Acta Paediatr Scand 65:773–775, 1976
Tytgat GM, Collem D, Verstraete M: Metabolism of fibrinogen in cirrhosis of the liver. J Clin Invest 50:1690–1701, 1971
Author information
Authors and Affiliations
Additional information
Portions of this data have been published in abstract form (Gastroenterology 76(5), part 2:1155, May 1979) and presented to the American Association for the Study of Liver Diseases, New Orleans, May 22, 1979.
Rights and permissions
About this article
Cite this article
Hoefs, J., Barnes, T. & Halle, P. Intraperitoneal coagulation in chronic liver disease ascites. Digest Dis Sci 26, 518–522 (1981). https://doi.org/10.1007/BF01308100
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01308100