Effect of antibacterial chemotherapeutic preparations of the synthesis of p-aminohil'puric acid in rat liver slices

Summary

The effect of chemotherapeutic preparations on the synthesis of peptide bonds was studied.

The reaction of synthesis of para-aminohippuric acid (PAHA) in sections of a rat's liver from para-aminobenzoic acid (PABA) and glycine was used. This method was described by P. P. Cohen and R. W. Gilwery. It was established that antituberculous chemotherapeutic preparation Tubazid, Ftivazid, Tibon, and streptomycm do not disturb biosynthesis of para-aminohippuric acid by liver slices. Penicillin, chloramphenicol. syntomycin, dextromycetin and chlortetracyclin in low concentrations, which correspond to therapeutic, have no effect on the above reactions of biosynthesis. In high concentrations these drugs suppress this reaction up to complete inhibition. Depression of reaction of biosynthesis of PAHA by chloramphenicol and its stereolsomers, penicillin, and chlortetracyclin may be explained by similarity of the chemical structure of the depressing substances with the products of this reaction.