Vascular permeability in some diseases of the central and peripheral nervous systems

Summary

Permeability of blood vessels to Na²⁴ was studied in the direction of tissues to blood and vice versa. These investigations were conducted in healthy individuals as well as in patients with diencephalic lesions and with pain syndromes of various etiology.

Pronounced delay of removal of Na²⁴ from the blood into the tissues was noted in diencephalic patients with increased permeability in tissue to blood direction. A more rapid removal of Na²⁴ from the blood was revealed in patients with reduced permeability from the tissues into the blood. The rapidity of Na²⁴ removal from the blood into the tissues in the patients with pain syndromes of various etiology is different (its velocity is increased in one case and decreased in the other). Certain vegetotropic substances widely used in the clinic (such as sympatol, and proserine) were used for directed change of permeability. It was established that following administration of sympatol absorption of Na²⁴ which was injected subcutaneously is greatly delayed.