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Intestinal epithelial function: The case for immunophysiological regulation

Implications for disease (second of two parts)

Digestive Diseases and Sciences volume 38, pages 1735–1745 (1993)Cite this article

Abstract

Substantial amounts of data have been reported showing a role for immunomodulation of epithelial function (particularly ion secretion and permeability) using animal models of anaphylactic reactions. In part one of this review we outlined the main immune cell types and mediators/cytokines that are currently known to influence epithelial physiology either directly, or indirectly via an intermediate cell type. Here we will expand on the significance of these studies and show how antigenic activation of the mucosal immune system can evoke changes in epithelial function that may be beneficial to the host by mediating loss/inactivation of the antigen. However, a continued and inappropriate immune stimulation can lead to pathophysiological reactions and disease. Thus, we will present data on immune regulation of epithelial function with direct applicability to understanding the mechanism underlying human intestinal inflammatory and secretory disease. Finally, we highlight key strategic points in the cascade of immune events that can control epithelial function and thus may be of relevance in the formulation of new therapeutic approaches to intestinal inflammation.

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  1. Intestinal Disease Research Unit, Department of Pathology, Faculty of Health Science, HSC-3N5, McMaster University, 1200 Main St. West, L8N 3Z5, Hamilton, Ontario, Canada

    Derek M. McKay PhD &  Mary H. Perdue PhD

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  1. Derek M. McKay PhD
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McKay, D.M., Perdue, M.H. Intestinal epithelial function: The case for immunophysiological regulation. Digest Dis Sci 38, 1735–1745 (1993). https://doi.org/10.1007/BF01303185

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Key Words

  • immunophysiology
  • intestinal hypersensitivity
  • immune system
  • mast cell
  • inflammatory mediator
  • cytokine
  • ion secretion
  • anaphylaxis
  • secretory disease