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Digestive Diseases and Sciences

, Volume 38, Issue 9, pp 1614–1618 | Cite as

Multiple vitamin status in Crohn's disease

Correlation with disease activity
  • Fumitoshi Kuroki
  • Mitsuo Iida
  • Masaya Tominaga
  • Takayuki Matsumoto
  • Katsuya Hirakawa
  • Shizuo Sugiyama
  • Masatoshi Fujishima
Original Articles

Abstract

We measured serum, blood, or red cell concentrations of various vitamins in 24 patients with Crohn's disease who had been free from any nutritional treatment, and compared them with those in 24 healthy controls. Twelve of the patients were affected in the small bowel only, two in the large bowel only, and the remaining 10 in both the small and large bowel. The fat-soluble vitamins A and E were significantly decreased in patients with Crohn's disease compared to controls. Among the water-soluble vitamins, vitamins B1, B2, and B6, and folic acid were more depleted in patients with Crohn's disease than in the controls, whereas vitamins B12 and C, nicotinic acid, and biotin were not different between the two groups, and pantothenic acid was increased in patients with Crohn's disease. In addition, vitamin B2 and nicotinic acid showed a negative correlation with the Crohn's disease activity index. These findings suggest that there is a variety of vitamin deficiencies in Crohn's disease prior to treatment and also that concentrations of some vitamins, such as vitamin B2 and nicotinic acid, may reflect the severity of the disease.

Key Words

inflammatory bowel disease Crohn's disease nutrition vitamin 

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References

  1. 1.
    Harries AD, Heatley RV: Nutritional disturbances in Crohn's disease. Postgrad Med J 59:690–697, 1983Google Scholar
  2. 2.
    Fernandez-Banares F, Abad-Lacruz A, Xiol X, Gine JJ, Dolz C, Cabre E, Esteve M, Gonzalez-Huix F, Gassull MA: Vitamin status in patients with inflammatory bowel disease. Am J Gastroenterol 84:744–748, 1989Google Scholar
  3. 3.
    Seidman E, LeLeiko N, Ament M, Berman W, Caplan D, Evans J, Kocoshis S, Lake A, Motil K, Sutphen J, Thomas D: Nutritional issues in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr 12:424–438, 1991Google Scholar
  4. 4.
    Yarnis H, Marshak RH, Crohn BB: Ileocolitis., JAMA 164:7–13, 1957Google Scholar
  5. 5.
    Cooke WT: Nutritional and metabolic factors in the aetiology and treatment of regional ileitis. Ann R Coll Surgeons Engl 17:137–158, 1955Google Scholar
  6. 6.
    Heatley RV: Assessing nutritional state in inflammatory bowel disease. Gut 27:61–66, 1986Google Scholar
  7. 7.
    Krause U, Bergman L, Norlen BJ: A clinical study based on 186 patients. Scand J Gastroenterol 6:97–108, 1971Google Scholar
  8. 8.
    Elsborg L, Larsen L: Folate deficiency in chronic inflammatory bowel diseases. Scand J Gastroenterol 14:1019–1024, 1979Google Scholar
  9. 9.
    Gee MI, Grace MGA, Wensel RH, Sherbaniuk RW, Thomson ABR: Nutritional status of gastroenterology outpatients: Comparison of inflammatory bowel disease with functional disorders. J Am Diet Assoc 85:1591–1599, 1985Google Scholar
  10. 10.
    Dotevall G, Kock NG: Absorption studies in regional enterocolitis (Mb. Crohn). Scand J Gastroenterol 3:293–298, 1968Google Scholar
  11. 11.
    Dyer NH, Child JA, Mollin DL, Dawson AM: Anemia in Crohn's disease. Q J Med 164:419–436, 1972Google Scholar
  12. 12.
    Imes S, Dinwoodie A, Walker K, Pinchbeck B, Thomson ABR: Vitamin C status in 137 outpatients with Crohn's disease: Effect of diet counseling. J Clin Gastroenterol 8:443–446, 1986Google Scholar
  13. 13.
    Gerson CD, Fabry EM: Ascorbic acid deficiency and fistula formation in regional enteritis. Gastroenterology 67:428–433, 1974Google Scholar
  14. 14.
    Cox EV, Gaddie R, Matthews D, Cooke WT, Meynell MJ: An inter-relationship between ascorbic acid and cyanocobalamin. Clin Sci 17:681–692, 1958Google Scholar
  15. 15.
    Main ANH, Mills PR, Russell RI, Bronte-Stewart J, Nelson LM, McIelland A, Shenkin A: Vitamin A deficiency in Crohn's disease. Gut 24:1169–1175, 1983Google Scholar
  16. 16.
    Imes S, Pinchbeck B, Dinwoodie A, Walker K, Thomson ABR: Vitamin A status in 137 patients with Crohn's disease. Digestion 37:166–170, 1987Google Scholar
  17. 17.
    Okabe N, Urabe K, Fujita K, Yamamoto T, Yao T: Biotin effects in Crohn's disease. Dig Dis Sci 33:1495–1496, 1988Google Scholar
  18. 18.
    Best WR, Becktel JM, Singleton JW, Kern F: Development of a Crohn's disease activity index. Gastroenterology 70:439–444, 1976Google Scholar
  19. 19.
    Abe K, Ohmae M, Kawabe K, Katsui G: Application of microparticle columns for the high-performance liquid chromatographic determination of vitamins A, E and ubiquinine. Vitamins (Jpn) 53:385–390, 1979Google Scholar
  20. 20.
    Fujiwara M: Determination of thiamine by the thiochrome reaction. Vitamins (Jpn) 9:148–155, 1955Google Scholar
  21. 21.
    Yagi K, Kikuchi S, Kariya T: Micro-determination of riboflavin in blood. Vitamins (Jpn) 8:450–451, 1955Google Scholar
  22. 22.
    Sundaresan PR, Coursin DB: Microassay of pyridoxal phosphate usingl-tyrosine-1-14C and tyrosine apodecarboxylase. Methods Enzymol 18:509–512, 1970Google Scholar
  23. 23.
    Wide L, Killander A: A radiosorbent technique for the assay of serum vitamin B12. Scand J Clin Lab Invest 27:151–159, 1971Google Scholar
  24. 24.
    Omaye ST, Turnbull JD, Sauberlich HE: Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol 62:3–11, 1979Google Scholar
  25. 25.
    Niimura T: Microbiological assay of nicotinic acid, pantothenic acid and biotin. Vitamins (Jpn) 12:106–114, 1957Google Scholar
  26. 26.
    Goodman DS: Vitamin A transport and retinol-binding protein metabolism. Vitam Horm 32:167–180, 1974Google Scholar
  27. 27.
    Goodman DS: Retinol-binding protein, prealbumin and vitamin A transport.In Trace Components of Plasma: Isolation and Clinical Significance. GS Jamieson, TJ Greenwalt (eds). New York, Liss, 1976, pp 313–330Google Scholar
  28. 28.
    Horwitt MK, Harvey CC, Dahm CH, Searcy MT: Relationship between tocopherol and serum lipid levels for determination of nutritional adequacy. Ann NY Acad Sci 203:223–236, 1972Google Scholar
  29. 29.
    Dyckner T, EK B, Nyhlin H, Wester PO: Aggravation of thiamine deficiency by magnesium depletion. Acta Med Scand 218:129–131 1985Google Scholar
  30. 30.
    Roth KS: Biotin in clinical medicine—a review. Am J Clin Nutr 34:1967–1974, 1981Google Scholar
  31. 31.
    Pollack S, Enat R, Haim S, Zinder O, Barzilai D: Pellagra as the presenting manifestation of Crohn's disease. Gastroenterology 82:948–952, 1982Google Scholar
  32. 32.
    Binder HJ, Ptak T: Jejunal absorption of water and electrolytes in inflammatory bowel disease. J Lab Clin Med 76:915–924, 1970Google Scholar

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Fumitoshi Kuroki
    • 1
    • 2
  • Mitsuo Iida
    • 1
    • 2
  • Masaya Tominaga
    • 1
    • 2
  • Takayuki Matsumoto
    • 1
    • 2
  • Katsuya Hirakawa
    • 1
    • 2
  • Shizuo Sugiyama
    • 1
    • 2
  • Masatoshi Fujishima
    • 1
    • 2
  1. 1.Second Department of Internal Medicine, Faculty of MedicineKyushu UniversityFukuokaJapan
  2. 2.SS Pharmaceutical Company, Ltd.TokyoJapan

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