Summary
Administration of 0.025–0.1 mg/kg of apomorphine i.p. to mice produced a dose-dependent locomotor depression. Haloperidol, 0.025 mg/kg, produced locomotor stimulation, whereas 0.1 mg/kg caused locomotor depression. Pretreatment with haloperidol also reversed the depression caused by apomorphine. The functional antagonism is discussed in terms of a possible agonist-antagonist interaction on dopaminergic autoreceptors.
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Strömbom, U. Antagonism by haloperidol of locomotor depression induced by small doses of apomorphine. J. Neural Transmission 40, 191–194 (1977). https://doi.org/10.1007/BF01300133
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DOI: https://doi.org/10.1007/BF01300133