Skip to main content

Effects of beta-adrenoceptor blocking drugs on human sigmoid colonic motility

Abstract

Effects of propranolol and metoprolol on sigmoid colonic motility were studied in 12 healthy volunteers in a double-blind randomized fashion. Colonic pressure was recorded 15–18 cm from anus and contractile activity quantified for periods of 25 min. On separate days propranolol, metoprolol, and placebo, respectively, was administered intravenously preceded by a control period. After propranolol, 10 mg intravenously, pressure activity increased significantly from 3.8±1.1 (sem) kPa×min (28±8 mm Hg×min) to 5.9±1.0 kPa×min (44±8 mm Hg×min) (P<0.001). Also, after propranolol, 5 mg intravenously, the pressure activity was increased (P<0.05). After metoprolol, 10 mg intravenously, contractile activity increased from 4.3±0.9 kPa×min (32±7 mm Hg×min) to 6.1±1.0 kPa×min (46±8 mm Hg×min) (P<0.01). The two drugs caused equipotent reduction of heart rate. After placebo, no effect on sigmoid pressure or heart rate was observed. The study shows that unselective (propranolol) andβ 1-selective (metoprolol) β-blocking drugs enhance distal colonic pressure in man. Colonic motility seems to be under sympathetic β-adrenergic influence even under fairly unstrained conditions.

This is a preview of subscription content, access via your institution.

References

  1. 1.

    Daniel EE: Pharmacology of the gastrointestinal tract.In Handbook of Physiology, Section 6: Alimentary Canal, Vol IV, Motility CF Code (ed). Washington, American Physiology Society, 1968, pp 2267–2324

    Google Scholar 

  2. 2.

    Furness JB, Costa M: The adrenergic innervation of the gastrointestinal tract. Rev Physiol 69:1–51, 1974

    Google Scholar 

  3. 3.

    Furness, JB, Costa M: Adynamic ileus, its pathogenesis and treatment. Med Biol 52:82–89, 1974

    Google Scholar 

  4. 4.

    Zfass AM, Prince R, Allen FN, Farrar JT: Inhibitory beta adrenergic receptors in the human distal esophagus. Am J Dig Dis 15:303–310, 1970

    Google Scholar 

  5. 5.

    Tkaczewski W, Chojnacki J: Gastric emptying after adrenolytic agents in duodenal ulcer patients. Hepato-Gastroenterology 1980(Suppl):107, 1980 (Abstracts of the XI International Congress of Gastroenterology)

    Google Scholar 

  6. 6.

    Abrahamsson H, Dotevall G: Effects of propranolol on colonic pressure in patients with irritable bowel syndrome. Scand J Gastroenterol 16:1021–1024, 1981

    Google Scholar 

  7. 7.

    Harvey, RF: The irritable bowel syndrome. Hormonal influences. Clin Gastroenterol 6:631–641, 1977

    Google Scholar 

  8. 8.

    Ervik M: Quantitative determination of metoprolol in plasma and urine by gas chromatography. Acta Pharmacol Toxicol 36(Suppl V):136–144, 1975

    Google Scholar 

  9. 9.

    Glise H: Reflex inhibition of gastric motility in response to abdominal trauma. Thesis, Department of Physiology, University of Göteborg, Sweden, 1980, pp 1–36

    Google Scholar 

  10. 10.

    Glise H, Lindahl BO, Abrahamsson H: Reflex adrenergic inhibition of gastric motility by nociceptive intestinal stimulation and peritoneal irritation in the cat. Scand J Gastroenterol 15:674–681, 1980

    Google Scholar 

  11. 11.

    Glise H, Abrahamsson H: Spino-vagal nonadrenergic inhibition of gastric motility elicited by abdominal nociceptive stimulation in the cat. Scand J Gastroenterol 15:665–672, 1980

    Google Scholar 

  12. 12.

    Neeley J, Catchpole BM: An analysis of the autonomic control of gastrointestinal motility in the cat. Gut 8:230–241, 1967

    Google Scholar 

  13. 13.

    Morris AI, Turnberg LA: Influence of isoproterenol and propranolol on human intestinal transportin vivo. Gastroenterology 81:1076–1079, 1981

    Google Scholar 

  14. 14.

    Ek B, Lundgren B: Characterization of beta-adrenoceptors mediating the inhibition of spontaneous contractile activity in isolated cat colonstrips. Acta Physiol Scand Suppl 473:43, 1979

    Google Scholar 

  15. 15.

    Jonsson G, Regårdh C-G: Clinical pharmacokinetics of beta-adrenoceptor blocking drugs. Clin Pharmacokinet 1:233–263, 1976

    Google Scholar 

  16. 16.

    Whitehead WE, Engel BT, Schuster MM: Irritable bowel syndrome. Physiological and psychological differences between diarrhoea-predominant and constipation-predominant patients. Dig Dis Sci 25:404–413, 1980

    Google Scholar 

  17. 17.

    Dotremont G, DeGest H: Klinische ervaringen met propranolol. Ned T Geneesk 24:369, 1968

    Google Scholar 

  18. 18.

    Stafford A: Drugs acting on the heart.In Side Effects of Drugs. A Survey of Unwanted Effects of Drugs Reported in 1968–1971, Vol VII. L Meylee, A Herxheimer, (eds). Amsterdam, Excerpta Medica, 1972, pp 269–296

    Google Scholar 

  19. 19.

    Fielding JF: Timolol treatment in the irritable bowel syndrome. Digestion 22:155–158, 1981

    Google Scholar 

Download references

Author information

Affiliations

Authors

Additional information

This study was supported by the Swedish Society for Medical Sciences.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Abrahamsson, H., Lyrenäs, E. & Dotevall, G. Effects of beta-adrenoceptor blocking drugs on human sigmoid colonic motility. Digest Dis Sci 28, 590–594 (1983). https://doi.org/10.1007/BF01299918

Download citation

Keywords

  • Public Health
  • Placebo
  • Heart Rate
  • Healthy Volunteer
  • Propranolol