Digestive Diseases and Sciences

, Volume 38, Issue 12, pp 2151–2155 | Cite as

Prevalence of hepatitis C virus infection in asymptomatic anti-HIV1 negative pregnant women and their children

  • Patrick Marcellin
  • Jacques Bernuau
  • Michèle Martinot-Peignoux
  • Daniel Larzul
  • Li-Zhe Xu
  • Sebastien Tran
  • Annie Bezeaud
  • Marie-Christine Guimont
  • Michel Levardon
  • Pascale Aumont
  • Serge Erlinger
  • Jean-Pierre Benhamou
Original Articles

Abstract

The prevalence of hepatitis C virus (HCV) infection was studied prospectively in pregnant women in France and their children by detection of anti-HCV with second-generation ELISA (ELISA2). In ELISA2-positive women, anti-HCV was detected with second- and third-generation RIBA (RIBA2 and RIBA3) and serum HCV RNA was detected with PCR. Among 670 women, anti-HIV1-negative, 26 (3.9%) were positive with ELISA2. RIBA2 was positive in 13 and HCV RNA was found in 10. Ten ELISA2-positive women had a further evaluation with assessment of HCV infection in their children. Among the 10 children born to the index pregnancy, only one was positive with ELISA2 and RIBA2 but negative with RIBA3 and PCR; the nine other children were ELISA2, RIBA2, RIBA3, and PCR negative. All 26 siblings (2–16 years old), of whom 14 were born to PCR-positive mothers, were ELISA2 and RIBA2 negative. We conclude that among anti-HIV1-negative pregnant women with normal serum ALT levels, the prevalence of HCV infection is relatively high but the risk for mother-to-infant transmission of HCV seems to be low.

Key Words

anti-HCV hepatitis C virus polymerase chain reaction mother-to-infant transmission epidemiology 

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References

  1. 1.
    Kuo G, Choo QL, Alter HJ, et al: An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 244:362–364, 1989Google Scholar
  2. 2.
    Van der Poel CL, Cuypers HT, Reesink HW, et al: Confirmation of hepatitis C virus infection by new recombinant immunoblot assay. Lancet 337:317–319, 1991Google Scholar
  3. 3.
    Marcellin P, Martinot-Peignoux M, Boyer N, et al: Second generation (RIBA) test in diagnosis of chronic hepatitis C. Lancet 337:551–552, 1991Google Scholar
  4. 4.
    Garson JA, Tedder RS, Briggs M, et al: Detection of hepatitis C viral sequences in blood donations by “nested” polymerase chain reaction and prediction of infectivity. Lancet 335:1419–1422, 1990Google Scholar
  5. 5.
    Martinot-Peignoux M, Marcellin P, Xu LZ, et al: Reactivity to c33c antigen as a marker of hepatitis C virus multiplication. J Infect Dis 165:595–596, 1992 (letter)Google Scholar
  6. 6.
    Kwok S, Higuchi R: Avoiding false positives with PCR. Nature 339:237–238, 1989Google Scholar
  7. 7.
    Pillonel J, Courouce AM, Laporte A, Brunet JB: Situation en France: Le dépistage du VIH, de la syphilis et des hépatites B et C dans les établissements de tranfusion sanguine (E.T.S.). Bull Epidemiol Hebd 39:185–187, 1992Google Scholar
  8. 8.
    Roudot-Thoraval F, Deforges L, Girollet PP, et al: Prévalence des anticorps dirigés contre le virus de l'hépatite C (tests ELISA 2 et RIBA 2) dans une population de femmes enceintes en France. Gastroenterol Clin Biol 16:255–259, 1992Google Scholar
  9. 9.
    Reinus JF, Leikin EL, Alter HJ, Cheung L, Shindo M, Jett B, Piazza S, Wai-Kuo Shih J: Failure to detect vertical transmission of hepatitis C virus. Ann Intern Med 117:881–886, 1992Google Scholar
  10. 10.
    Giovannini M, Tagger A, Ribero ML, et al: Maternal-infant transmission of hepatitis C virus and HIV infections: A possible interaction. Lancet 335:1166, 1990Google Scholar
  11. 11.
    Thaler MM, Choong-Kee P, Landers DV, et al: Vertical transmission of hepatitis C virus. Lancet. 338:17–18, 1991Google Scholar
  12. 12.
    Novati R, Thiers V, d'Arminio Monforte A, et al: Mother-to-child transmission of hepatitis C virus detected by nested polymerase chain reaction. J Infect Dis 165:720–723, 1992Google Scholar
  13. 13.
    Wejstal R, Anders W, Mansson AS, Hermodsson S, Norkrans G: Mother-to-infant transmission of hepatitis C virus. Ann Intern Med 117:887–890, 1992Google Scholar

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Patrick Marcellin
    • 1
    • 2
    • 3
    • 4
    • 5
  • Jacques Bernuau
    • 1
    • 2
    • 3
    • 4
    • 5
  • Michèle Martinot-Peignoux
    • 1
    • 2
    • 3
    • 4
    • 5
  • Daniel Larzul
    • 1
    • 2
    • 3
    • 4
    • 5
  • Li-Zhe Xu
    • 1
    • 2
    • 3
    • 4
    • 5
  • Sebastien Tran
    • 1
    • 2
    • 3
    • 4
    • 5
  • Annie Bezeaud
    • 1
    • 2
    • 3
    • 4
    • 5
  • Marie-Christine Guimont
    • 1
    • 2
    • 3
    • 4
    • 5
  • Michel Levardon
    • 1
    • 2
    • 3
    • 4
    • 5
  • Pascale Aumont
    • 1
    • 2
    • 3
    • 4
    • 5
  • Serge Erlinger
    • 1
    • 2
    • 3
    • 4
    • 5
  • Jean-Pierre Benhamou
    • 1
    • 2
    • 3
    • 4
    • 5
  1. 1.Service d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM)Hôpital BeaujonClichyFrance
  2. 2.Service d'Hématologie et d'Immunologie, Laboratoire de BiochimieHôpital BeaujonClichyFrance
  3. 3.Service de Gynécologie et ObstétriqueHôpital BeaujonClichyFrance
  4. 4.Molecular Biology DepartmentEIBETPlaisirFrance
  5. 5.Ortho Diagnostic SystemsRoissyFrance

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