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Quantitative effect of oral feeding on gastrointestinal myoelectric activity in the conscious dog

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Abstract

Gastrointestinal myoelectric activity was recorded in seven studies in five dogs during two hours of fasting immediately followed by feeding and subsequent recording for four hours. In four studies serial plasma samples were taken for radioimmunoassay of insulin and gastrin. In all animals there was a significant reduction (P<0.01) in gastric basic electrical rhythm (BER) frequency on feeding which was sustained throughout the postprandial period. There was no change in the duodenal BER. Feeding induced a significant (P<0.01) increase in overall jejunal and ileal (but not duodenal) spike activity. Ileal (but not jejunal) spike activity again increased significantly (P<0.05) after the first two postprandial hours. The changes in serum gastrin or in serum insulin did not appear to account for most of the observed changes in myoelectric activity, suggesting that other humoral and/or neural factors mediate the response to food.

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Authors and Affiliations

  1. Department of Gastrointestinal Science, London Hospital Medical College, Whitechapel Road, E1 1BB, London, England

    David Wingate FRCP, Elizabeth Pearce MA, Anne Ling MIScT, Barbara Boucher FRCP, Hilary Thompson FRCS & Michael Hutton BA

Authors
  1. David Wingate FRCP
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  2. Elizabeth Pearce MA
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  3. Anne Ling MIScT
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  4. Barbara Boucher FRCP
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  5. Hilary Thompson FRCS
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  6. Michael Hutton BA
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Additional information

This project was carried out under the grants from the Wellcome Trust, the University of London Central Research Fund, and the Medical Research Council of Great Britain.

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Wingate, D., Pearce, E., Ling, A. et al. Quantitative effect of oral feeding on gastrointestinal myoelectric activity in the conscious dog. Digest Dis Sci 24, 417–423 (1979). https://doi.org/10.1007/BF01299823

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  • DOI: https://doi.org/10.1007/BF01299823

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