Skip to main content
Log in

Jejunal perforation possibly induced by slow-release potassium in a patient with Crohn's disease

  • Case Report
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Summary

A case of small bowel ulceration and perforation possibly due to therapy with Klotrix in a patient with Crohn's disease is presented. Following emergent surgery with creation of a diverting loop jejunostomy, subsequent reestablishment of intestinal continuity was carried out with excellent clinical results. Gastrointestinal mucosal lesions possibly due to wax-matrix potassium chloride preparations are reviewed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Allen CA, Boley SJ, Schultz L, Schwartz S: Potassiuminduced lesions of the small bowel. II. Pathology and Pathogenesis. JAMA 193:1001–1006, 1965

    Google Scholar 

  2. Maggio-Cavaliere MB, Dirkstein WG, Arnold JD, Berger AE: Absence of gastrointestinal bleeding with controlled-release potassium chloride tablets. Clin Pharmacol Ther 16:685–690, 1974

    Google Scholar 

  3. Boley SF, Allen AC, Schultz L, Schwartz S Potassium-induced lesions of the small bowel. I. Clinical Aspects. JAMA 193:997–1000, 1965

    Google Scholar 

  4. Heffernan SJ, Murphy JJ: Ulceration of the small intestine and slow-release potassium tablets. Br Med J 2:746, 1975

    Google Scholar 

  5. Farquharson-Roberts MA, Giddings AEB, Nunn AJ: Perforation of small bowel due to slow-release potassium chloride (Slow-K). Br Med J 2:206, 1975

    Google Scholar 

  6. Weiss SM, Rutenberg HL, Paskin DL, Zaren HA: Gut lesions due to slow-release KCl tablets. N Engl J Med 296:111–112, 1977

    Google Scholar 

  7. Lofgren RP, Rothe PR, Carlson GJ: Jejunal perforation associated with slow-release potassium chloride therapy. South Med J 75:1154–1155, 1982

    Google Scholar 

  8. McAvoy BR: Mouth ulceration and slow-release potassium tablets. Br Med J 2:164–165, 1974

    Google Scholar 

  9. Lambert JR, Newman A: Ulceration and stricture of the esophagus due to oral potassium chloride (slow-release tablet) therapy. Am J Gastroenterol 73:508–511, 1980

    Google Scholar 

  10. McMahon FG, Akdamar K: Gastric ulceration after “Slow-K.”. N Engl J Med 295:733–734, 1976

    Google Scholar 

  11. McMahon FG, Akdamar K, Ryan JR, Ertan A: Upper gastrointestinal lesions after potassium chloride supplements: A controlled clinical trial. Lancet 2:1059–1061, 1982

    Google Scholar 

  12. Glenn F, Grafe WR: Surgical complications of adrenal steroid therapy. Ann Surg 165:1023–1034, 1967

    Google Scholar 

  13. Markowitz AM: The less common perforations of the small bowel. Ann Surg 152:240–257, 1963

    Google Scholar 

  14. Watson MR: Primary nonspecific ulceration of the small bowel. Arch Surg 87:600–603, 1963

    Google Scholar 

  15. Clark PA, Hsai YE, Huntsman RG: Toxic complications of treatment with 6-mercaptopurine. Br Med J 1:393–395, 1960

    Google Scholar 

  16. Waye JD, Lithgrow C: Small-bowel perforations in regional enteritis. Gastroenterology 53:625–629, 1967

    Google Scholar 

  17. Abascal J, Diaz-Rojas F, Jorge J, Sanchez-Vegazo I, Escartin P, Abreu L, Chantar C: Free perforation of the small bowel in Crohn's disease. World J Surg 6:216–220, 1982

    Google Scholar 

  18. Menguy R: Surgical management of free perforation of the small intestine complicating regional enteritis. Ann Surg 175:178–189, 1972

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

The opinions or assertions expressed herein are those of the authors and do not necessarily reflect the views of the Department of the Navy or the naval service at large.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brower, R.A. Jejunal perforation possibly induced by slow-release potassium in a patient with Crohn's disease. Digest Dis Sci 31, 1387–1390 (1986). https://doi.org/10.1007/BF01299819

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01299819

Keywords

Navigation