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Double-blind crossover trial of prostaglandin E2 in postgastrectomy reflux gastritis

Digestive Diseases and Sciences volume 31, pages 1281–1286 (1986)Cite this article

Abstract

Excessive Enterogastric reflux following partial gastrectomy is believed to be responsible for bilious regurgitation, vomiting, nausea, and epigastric pain. At endoscopy, striking erythema and inflammatory changes of the gastric mucosa may be seen. The nonsurgical treatment for this syndrome is unsatisfactory. Because of the potential pathogenetic role of regurgitating bile acids, lysolecithin, and pancreatic secretions, it seemed relevant to find out whether prostaglandin E2 (PGE2) in a dose of 0.5 mg qid could protect the gastric mucosa from further damage and thereby lead to symptomatic improvement. The results of this controlled doubled-blind crossover trial, comparing PGE2 and placebo, in the treatment of postgastrectomy reflux gastritis reveal no significant differences between PGE2 and placebo with regard to symptoms, endoscopic features, and histologic evidence of inflammatory changes. Thus, prostaglandin E2 in the dose used appears incapable of improving postagastrectomy reflux gastritis in patients with mild to moderate degrees of this entity.

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Author notes

  1. J. J. Nicolai MD

    Present address: Division of Gastroenterology, Ziekenhuis Leyenburg, The Hague

  2. J. van de Stadt MD

    Present address: Stichting Pathologische Anatomie Twente, en de Gelderse Achterhoek, Enschede

Affiliations

  1. Division of Gastroenterology—Hepatology, University of Amsterdam, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

    J. J. Nicolai MD,  J. van de Stadt MD &  G. N. J. Tytgat MD, PhD

Authors
  1. J. J. Nicolai MD
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  2. J. van de Stadt MD
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  3. G. N. J. Tytgat MD, PhD
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Nicolai, J.J., van de Stadt, J. & Tytgat, G.N.J. Double-blind crossover trial of prostaglandin E2 in postgastrectomy reflux gastritis. Digest Dis Sci 31, 1281–1286 (1986). https://doi.org/10.1007/BF01299803

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  • DOI: https://doi.org/10.1007/BF01299803

Keywords

  • Placebo
  • Bile Acid
  • PGE2
  • Gastritis
  • Gastric Mucosa