Skip to main content
SpringerLink
Log in

One gram of aspirin per day does not reduce risk of hospitalization for gallstone disease

  • Original Articles
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Data from 4524 patients in a randomized, controlled trial of aspirin were analyzed to determine if aspirin reduced the risk for hospitalization for gallstone disease. Aspirin at a dose of 1000 mg/day did not reduce the risk of hospitalization for gallstones. Hospitalization rates for gallstone disease were consistent with national rates, and the data confirmed previous associations of gallstone disease with age, elevated serum triglycerides, obesity, and female gender.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Broomfield PH, Chopra R, Sheinbaum R, Bonorris G, Silverman A, Schoenfield LJ, Marks JW: Effects of ursodeoxycholic acid and aspirin on the formation of lithogenic bile and gallstones during loss of weight. N Engl J Med 319:1567–1572, 1988

    Google Scholar 

  2. Hood K, Ruggpin DC, Gleeson D, Dowling RH: Prevention of gallstone recurrence by non-steroidal anti-inflammatory drugs. Lancet 2:1223–1225, 1988

    Google Scholar 

  3. Goldman G, Kahn PJ, Alon R, Wiznitzer T: Biliary colic treatment and acute cholecystitis prevention by prostaglandin inhibitor. Dig Dis Sci 34:809–811, 1989

    Google Scholar 

  4. LaMont JT, Turner BS Di Benedetto D, Handin R, Schafer AI: Arachidonic acid stimulates mucin secretion in prairie dog gallbladder. Am J Physiol 245:G92-G98, 1983

    Google Scholar 

  5. Lee SP, Carey MC, LaMont JT: Aspirin prevention of cholesterol gallstone formation in prairie dogs. Science 211:1429–1430, 1981

    Google Scholar 

  6. Aspirin Myocardial Infarction Study Research Group: A randomized, controlled trial of aspirin in persons recovered from myocardial infarction. JAMA 243:661–669, 1980

    Google Scholar 

  7. Schoenberger JA: Recruitment experience in the Aspirin Myocardial Infarction Study. Controlled Clinical Trials 8:74S-78S, 1987

    Google Scholar 

  8. Rothman KJ: Modern Epidemiology. Boston Little, Brown, 1986, pp 153–156, 171–172

    Google Scholar 

  9. Dixon WJ (ed): BMDP Statistical Software. Berkeley, University of California Press, 1988

    Google Scholar 

  10. Frost PH, Verter J, Miller D: Serum lipids and lipoproteins after myocardial infarction: associations with cardiovascular mortality and experience in the aspirin myocardial infarction study. Am Heart J 113:1356–1364, 1987

    Google Scholar 

  11. Kadziolka R, Nilsson R, Schersten T: Prevalence of hyperlipoproteinemia in men with gallstone disease. Scand J Gastroenterol 12:353–355, 1977

    Google Scholar 

  12. Scragg RKR, Calvert GD, Oliver JR: Plasma lipids and insulin in gall stone disease: A case-control study. Br Med J 289:521–525, 1984

    Google Scholar 

  13. Friedman GD, Kannel WB, Dawber TR: The epidemiology of gallbladder disease: Observations in the Framingham study. J Chron Dis 19:273–292, 1966

    Google Scholar 

  14. The Rome Group for Epidemiology and Prevention of Cholelithiasis (GREPCO): The epidemiology of gallstone disease in Rome, Italy. Part II. Factors associated with the disease. Hepatology 8:907–913, 1988

    Google Scholar 

  15. Scragg RKR, McMichael AJ, Baghurst PA: Diet, alcohol, and relative weight in gallstone disease: A case control study. Br Med J 288:1113–1119, 1984

    Google Scholar 

  16. Bennion LJ, Grundy SM: Risk factors for the development of cholelithiasis in man. N Engl J Med 299:1221–1227, 1978

    Google Scholar 

  17. Pixley F, Wilson D, McPherson K, Mann J: Effect of vegetarianism on development of gall stones in women. Br Med J 291:11–12, 1985

    Google Scholar 

  18. Barbara L, Sama C, Labate AMM, Taroni F, Rusticali AG, Festi D, Sapio C, Roda E, Banterle C, Puci A, Formentini F, Colasanti S, Nardin F: A population study on the prevalence of gallstone disease: The Sirmione study. Hepatology 7:913–917, 1987

    Google Scholar 

  19. Smith BF, LaMont JT: The pathogenesis of gallstones. Hosp Pract 19:93–104, 1984

    Google Scholar 

  20. National Center for Health Statistics: Inpatient Utilization of Short-stay Hospitals by Diagnosis: United States, 1979. DHHS Publication No. (PHS) 82-1274-1

  21. Laakso M, Suhonen M, Julkunen R, Pyorala K: Plasma insulin, serum lipids and lipoproteins in gall stone disease in non-insulin dependent diabetic subjects: A case control study. Gut 31:344–347, 1990

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Family Medicine, San Bernardino County Medical Center, 755 East Gilbert Street, 92404, San Bernardino, California

    John H. Kurata PhD (Director of Research), Jay Marks MD & David Abbey PhD

  2. Division of Family Medicine, UCLA School of Medicine, Los Angeles, California

    John H. Kurata PhD (Director of Research), Jay Marks MD & David Abbey PhD

  3. Department of Medicine and Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, California

    John H. Kurata PhD (Director of Research), Jay Marks MD & David Abbey PhD

  4. UCLA School of Medicine, Los Angeles, California

    John H. Kurata PhD (Director of Research), Jay Marks MD & David Abbey PhD

  5. Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, California

    John H. Kurata PhD (Director of Research), Jay Marks MD & David Abbey PhD

Authors
  1. John H. Kurata PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jay Marks MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David Abbey PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported in part by grants (NIDDK AM 17328 and NIDDK AM 37080) from the National Institutes of Health.

The original Aspirin Myocardial Infarction Study (AMIS) was sponsored by the National Heart, Lung, and Blood Institute, Bethesda, Maryland.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kurata, J.H., Marks, J. & Abbey, D. One gram of aspirin per day does not reduce risk of hospitalization for gallstone disease. Digest Dis Sci 36, 1110–1115 (1991). https://doi.org/10.1007/BF01297455

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01297455

Key Words

Search

Navigation