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Are animal models of colon cancer relevant to human disease

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References

  1. Druckrey H: Production of colonic carcinomas by 1,2-dialkylhydrazines and azoxyalkanes.In Burdette WJ (ed.) Carcinomas of Colon and Antecedent Epithelium. Spring-field, Illinois, Charles C. Thomas, 1970, pp 267–279

    Google Scholar 

  2. Newberne PM, Rogers AE: Adenocarcinoma of the colon. Animal model of human disease. Am J Pathol 72:541–544, 1973

    Google Scholar 

  3. Sunter JP, Appleton DR, Wright NA, Watson AJ: Pathological features of the colonic tumors induced in rats by the administration of 1,2-dimethylhydrazine. Virchows Arch B 29:211–223, 1978

    Google Scholar 

  4. Wiebecke B, Krey U, Lohrs U, Eder M: Morphological and autoradiographical investigations on experimental carcinogenesis in polyp development in the intestinal tract of rats and mice. Virchows Arch A 360:179–193, 1973

    Google Scholar 

  5. Maskens AP: Histogenesis and growth pattern of 1,2-dimethylhydrazine induced rat colon adenocarcinoma. Cancer Res 36:1585–1593, 1976

    Google Scholar 

  6. Filipe MI: Mucinous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine. Br J Cancer 32:60–77, 1975

    Google Scholar 

  7. Committee on Diet, Nutrition and Cancer, National Research Council: Diet, Nutrition, and Cancer. Washington, DC, National Academy Press, 1982

  8. Weisberger JH, Wynder EL, Horne CL: Nutritional factors in etiologic mechanisms in the causation of gastrointestinal cancers. Cancer 50:2541–2549, 1982

    Google Scholar 

  9. Walker ARP: Cancer and diet, with special reference to intakes of fat and fiber. Am J Clin Nutr 29:1417–1426, 1976

    Google Scholar 

  10. Armstrong B, Doll R: Environmental factors and cancer incidence and mortality in different countries with special reference to dietary practices. Int J Cancer 15:617–631, 1975

    Google Scholar 

  11. Kinlen LJ: Fat and cancer. Br Med J 286:1081–1082, 1983

    Google Scholar 

  12. Willett WC, MacMahon B: Diet and cancer. N Engl J Med 310:633–638, 697–703, 1984

    Google Scholar 

  13. Ward JM: Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats. Lab Invest 30:505–513, 1974

    Google Scholar 

  14. Pozhariski KM, Likhachev AJ, Klimashevski VF, Shaposhnikov JD: Experimental intestinal cancer research with special reference to human pathology. Adv Cancer Res 30:165–237, 1979

    Google Scholar 

  15. Morson BC: The pathogenesis of colorectal cancer. Philadelphia, WB Saunders, 1978

    Google Scholar 

  16. Gilbertson VA, Nelms JM: The prevention of invasive cancer of the rectum. Cancer 41:11–37, 1978

    Google Scholar 

  17. Haase P, Cowan DM, Knolls JC, Cooper EH: Evaluation of dimethylhydrazine induced tumors in mice as a model system for colorectal cancer. Br J Cancer 28:530–543, 1973

    Google Scholar 

  18. Chang YL: Histogenesis of symmetrical 1,2-dimethylhydrazine-induced neoplasms of the colon in the mouse. J Natl Cancer Inst 60:1405–1418, 1978

    Google Scholar 

  19. Buckwalter JA, Kent TH: Prognosis in surgical pathology of carcinoma of the colon. Surg Gynecol Obstet 66:611, 1938

    Google Scholar 

  20. Grinnell RS: Lymphatic metastases of carcinoma of colon and rectum. Ann Surg 131:494–506, 1950

    Google Scholar 

  21. Coller FA, Kay EB, MacIntyre RS: Regional lymphatic metastases of carcinoma of the rectum. Surgery 8:294–311, 1940

    Google Scholar 

  22. Brown CE, Warren S: Visceral metastases from rectal carcinoma. Surg Gynecol Obstet 66:611, 1938

    Google Scholar 

  23. Dionne L: The pattern of blood-borne metastases in carcinoma of the rectum. Cancer 18:775–781, 1965

    Google Scholar 

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Supported by Veterans Administration Research Associate Award #1312.

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Ahnen, D.J. Are animal models of colon cancer relevant to human disease. Digest Dis Sci 30, 103S–106S (1985). https://doi.org/10.1007/BF01296987

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