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Effects of antacids, cimetidine, and 16, 16-dimethyl prostaglandin E2 on acute gastric erosions in a spinal rat

Digestive Diseases and Sciences volume 27, pages 220–224 (1982)Cite this article

Abstract

Acute erosions of the stomach may occur in association with human spinal cord injuries. Erosion of the glandular portion of the stomach also occurs after cervical cord transection in the rat. Reports on the effects of antacids and cimetidine in the preventon of acute “stress” erosions in animals and humans have shown conflicting results. A prostaglandin analog, 16, 16-dimethyl prostaglandin E2 (16, 16-dmPGE2) has been shown to prevent gastric erosions in rats produced by nonsteroid antiinflammatory compounds. Cimetidine 50 mg/kg (intraperitoneal), 16,16-dmPGE2 10 μg/kg (intraperitoneal), and antacid 2 ml (intragastric) were individually given to groups of spinal rats at 0 and 4 hr. 16, 16-dmPGE2 and antacid both resulted in significant reduction in mean ulcer length compared to controls after 8 hr (P<0.05) whereas cimetidine showed no significant effect, even though cimetidine caused a significant decrease in gastric acid output compared to both 16, 16-dmPGE2 and controls (P<0.01). It is concluded that cimetidine on this dosage schedule is not effective in the prevention of gastric erosions in a cervical cord section rat model, whereas the ulceroprotective effects of 16, 16-dmPGE2 and antacids are significant. It is suggested that the gastric mucosal cells remain vulnerable to injury in the cimetidinetreated spinal rat due to secretory inhibition, but are protected by buffering action of antacids or by “cytoprotective” effects of prostaglandin

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Author information

Affiliations

  1. Department of Surgery, Sir Mortimer B. Davis-Jewish General Hospital, 3755 Côte Ste Catherine Road, H3T 1E2, Montreal, Quebec, Canada

    Harvey H. Sigman MD & Anton Gillich BSc

  2. Lady Davis Institute for Medical Research, H3T 1E2, Montreal, Quebec, Canada

    Harvey H. Sigman MD & Anton Gillich BSc

  3. McGill University, H3T 1E2, Montreal, Quebec, Canada

    Harvey H. Sigman MD & Anton Gillich BSc

Authors
  1. Harvey H. Sigman MD
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  2. Anton Gillich BSc
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Additional information

This work was supported by Medical Research Council of Canada grant MA-7041, and by Smith, Kline and French, Toronto, Ontario

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Sigman, H.H., Gillich, A. Effects of antacids, cimetidine, and 16, 16-dimethyl prostaglandin E2 on acute gastric erosions in a spinal rat. Digest Dis Sci 27, 220–224 (1982). https://doi.org/10.1007/BF01296919

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  • DOI: https://doi.org/10.1007/BF01296919

Keywords

  • Prostaglandin
  • Spinal Cord Injury
  • Cimetidine
  • Acid Output
  • Mucosal Cell