Digestive Diseases and Sciences

, Volume 27, Issue 3, pp 217–219 | Cite as

Cimetidine in the management of symptomatic patients with duodenitis

A double-blind controlled trial
  • M. Mackinnon
  • R. L. Willing
  • R. Whitehead
Original Articles

Abstract

Twenty-one adult outpatients with dyspepsia and endoscopically proven duodenitis without chronic ulceration completed a double-blind trial of either cimetidine (1 g/day) or placebo. Treatment with cimetidine for 6 weeks resulted in a significant improvement in symptoms and in the endoscopic appearance of the duodenitis when compared to treatment with placebo. The symptomatic and endoscopic inprovement, however, was not associated with any significant change in the histological grading of the duodenitis.

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References

  1. 1.
    Cotton PB, Price AB, Tighe DR, Beales SJM: Preliminary evaluation of “duodenitis” by endoscopy and biopsy. Br Med J 3:430–433, 1973Google Scholar
  2. 2.
    Gelzayd EA, Biederman MA, Gelfand DW: Changing concepts of duodenitis. Am J Gastroenterol 64:213–216, 1975Google Scholar
  3. 3.
    Gregg JA, Gerebedian M: Duodenitis. Am J Gastroenterol 61:177–184, 1974Google Scholar
  4. 4.
    Thomson WO, Joffe SN, Robertson AG, Less FD, Imrie CW: Is duodenitis a dyspeptic myth? Lancet 2:177–184, 1977Google Scholar
  5. 5.
    Blackwood WS, Mandgal DP, Pickard RG, Lawrence D, Northfield TC: Cimetidine in severe duodenal ulceration. Lancet 2:174–176, 1976Google Scholar
  6. 6.
    Gray GR, Smith IS, McKenzie I, Cream GP, Gillespie G: Oral cimetidine in severe duodenal ulceration. Lancet 1:4–7, 1977Google Scholar
  7. 7.
    Stephen JB, Lesna M, Venables CW: Endoscopic appearances and histological changen in ulcer-associated duodenitis. Br J Surg 65:438–441, 1978Google Scholar
  8. 8.
    Whitehead R, Roca M, Meikle DD, Skinner J, Truelove SC: The histological classification of duodenitis in fibreoptic biopsy specimens. Digestion 13:129–136, 1975Google Scholar
  9. 9.
    Whitehead R, Piris J: Morphological aspects of non-ulcer dyspepsia.In Cimetidine, C Wastell, P Lance (eds) Edinburgh, Churchill Livingstone, 1978, pp 111–124Google Scholar
  10. 10.
    La Brooy S, Lovell D, Misiewicz JJ: The treatment of nonulcer dyspepsia.In Cimetidine, C Wastell, P Lance (eds). Edinburgh, Churchill Livingstone, 1978, pp 131–137Google Scholar
  11. 11.
    Gilmore HM, Forrest JAH, Fettes M, Logan RFA, Heading RC: The effect of cimetidine on duodenitis.In Cimetidine, C Wastell, P Lance (eds). Edinburgh, Churchill Livingstone, 1978, pp 141–146Google Scholar

Copyright information

© Digestive Disease Systems, Inc. 1982

Authors and Affiliations

  • M. Mackinnon
    • 1
    • 2
  • R. L. Willing
    • 1
    • 2
  • R. Whitehead
    • 1
    • 2
  1. 1.Department of MedicineFlinders Medical CentreBedford Park
  2. 2.Department of HistopathologyFlinders Medical CentreBedford Park

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