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HLA-B13 and chronic calcific pancreatitis

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Abstract

In view of a possible role of genetic factors in the etiology of chronic calcific pancreatitis, we undertook a study of the frequency of HLA antigens in this disease. Sixty-four patients with chronic calcific pancreatitis were typed for the HLA-A,-B and-C loci. Fourteen of these 64 patients (21.9%) were found to have antigen B13 compared to 7.5% of 425 controls. These results have aP value of 0.00059 which remains significant (P=0.020) even when multiplied by the total number of antigens tested. Sex, alcoholism, age at the clinical onset of the disease, presence of pain, and diabetes had no apparent influence on the distribution of HLA alleles. The significant association between chronic calcific pancreatitis and HLA antigen B13 further supports the role of genetic factors in the etiology of the disease.

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Authors and Affiliations

  1. Pancreatic Disease Unit, Department of Medicine and Gastroenterology, University of Bologna, Bologna, Italy

    L. Gullo MD, P. L. Tabacchi MD, G. R. Corazza MD, F. Calanca MS, O. Campione MD & G. Labò MD

  2. I Surgical Clinic, University of Bologna, Bologna, Italy

    L. Gullo MD, P. L. Tabacchi MD, G. R. Corazza MD, F. Calanca MS, O. Campione MD & G. Labò MD

  3. St. Orsola Hospital, Bologna, Italy

    L. Gullo MD, P. L. Tabacchi MD, G. R. Corazza MD, F. Calanca MS, O. Campione MD & G. Labò MD

  4. Central Laboratory, Malpighi Hospital, Bologna, Italy

    L. Gullo MD, P. L. Tabacchi MD, G. R. Corazza MD, F. Calanca MS, O. Campione MD & G. Labò MD

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  1. L. Gullo MD
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  2. P. L. Tabacchi MD
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  3. G. R. Corazza MD
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  4. F. Calanca MS
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  5. O. Campione MD
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  6. G. Labò MD
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Gullo, L., Tabacchi, P.L., Corazza, G.R. et al. HLA-B13 and chronic calcific pancreatitis. Digest Dis Sci 27, 214–216 (1982). https://doi.org/10.1007/BF01296917

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  • DOI: https://doi.org/10.1007/BF01296917

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