Human gut hormone profiles in patients with short bowel syndrome
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We have studied gut hormone profiles in a small number of patients on treatment with home parenteral nutrition following near-total enterectomy who had no evidence of Inflammatory bowel disease and who were otherwise healthy. These and age- and sex-matched controls had gut hormone profiles measured after an overnight fast and a standard test meal. Circulating pancreatic glucagon concentrations and profiles were the same in both groups as were the Neurotensin and VIP. Peptide YY (PYY) concentrations and profiles were markedly raised in the short bowel group. It is suggested that the normal glucagon responses reflect the integrity of the remaining duodenum and pancreas. Circulating neurotensin and VIP originate largely from outside the bowel and so the removal of the gut source does not significantly affect their profiles. Enteroglucagon and PYY are secreted from terminal ileum and colon in response to unabsorbed food residues. The elevated circulating levels and profiles are consistent with those observed by others in patients with jejunoileal bypass or major resections in whom unabsorbed nutrients reach the colon.
Key Wordsgut hormone profiles short bowel syndrome
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- 1.Mughal M, Irving MH: Home parenteral nutrition in the United Kingdom and Ireland—a report of 200 cases. Lancet 2:383–387, 1986Google Scholar
- 2.Bloom SR, Long RG: Radioimmunoassay of Gut Regulatory Peptides. Philadelphia, WB Saunders, 1982Google Scholar
- 3.Adrian TE, Ferri G-L, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR: Human distribution and release of a putative new gut hormone Peptide YY. Gastroenterology 89:1070–1077, 1985Google Scholar
- 4.Bloom SR, Polak JM: Gut hormone concentrations in gastrointestinal disease. Clin Gastroenterol 9:785–798, 1980Google Scholar
- 5.Adrian TE, Savage AP, Bacarese-Hamilton AJ, Wolfe K, Besterman HS, Bloom SR: Peptide YY abnormalities in gastrointestinal disease. Gastroenterology 90:379–384, 1986Google Scholar
- 6.Greenberg GR, Buchan AMJ, McLeod RS, Preston P, Cohen Z: Gut hormone responses after reconstructive surgery for ulcerative colitis. Gut 30:1721–1730, 1989Google Scholar
- 7.Bloom SR, Besterman HS, Adrian TE, Christofides ND, Sarson DL, Mallinson RN, Pero A, Modigliani R: Gut hormone profiles following resection of large and small bowel. Gastroenterology 76:1101, 1979 (abstract)Google Scholar
- 8.Besterman HS, Sarson DL, Blackburn AM, Cleary J, Pilkington TRE, Bloom SR: The gut hormone profile in morbid obesity and following jejuno-ileal bypass. Scand J Gastroenterol 13(suppl 49):15, 1978Google Scholar
- 9.Greenburg GR, Wolman SL, Christofides ND, Bloom SR, Jeejeebhoy KN: Effect of total parenteral nutrition on gut hormone release in humans. Gastroenterology 80:988–993, 1981Google Scholar
- 10.Solcia E, Capella C, Buffa R, et al: Lausanne 1977 classification of gastroenteropancreatic endocrine cells.In Gut Hormones. SR Bloom (ed). Edinburgh, Churchill-Livingstone, 1980, pp 40–48Google Scholar
- 11.Mitchell SJ, Bloom SR: Measurement of fasting and post-prandial plasma VIP in man. Gut 19:1043–1048, 1978Google Scholar