Digestive Diseases and Sciences

, Volume 37, Issue 5, pp 641–644 | Cite as

Detection of hepatitis C virus-specific antigens in semen from non-A, non-B hepatitis patients

  • Girish J. Kotwal
  • Vinod K. Rustgi
  • Bahige M. Baroudy
Original Articles


Semen samples from nine patients clinically diagnosed as having non-A, non-B hepatitis (NANBH) were tested by an ELISA using antibodies raised in rabbits against HCV-specific specific antigens. The semen from all nine patients had elevated levels of HCV-specific antigen in comparison to semen from five healthy donors. Semen from five of the nine patients had significant levels of the HCV-specific antigen. Seven of the eight serum samples from these patients were reactive with the standard C-100 HCV ELISA. Eight of these nine patients had serum reactive for HCV-specific antibodies in our ELISA using HCV-specific antigens. This more direct evidence for viral presence supports the earlier epidemiological data suggesting that HCV could be transmitted sexually.

Key Words

hepatitis C antigens semen non-A, non-B hepatitis 


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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Girish J. Kotwal
    • 1
    • 2
  • Vinod K. Rustgi
    • 1
    • 2
  • Bahige M. Baroudy
    • 1
    • 2
  1. 1.Division of Molecular VirologyJames N. Gamble Institute of Medical ResearchCincinnati
  2. 2.INOVA Institute of Research and EducationFalls Church

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