Skip to main content
SpringerLink
Log in

Factors affecting plasma postheparin diamine oxidase activity

  • Original Articles
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Plasma postheparin diamine oxidase (DAO) activity has been evaluated for assessing disease activity in Crohn's disease (CD) and other intestinal disorders. Since the mechanism of the reduced plasma DAO activity is poorly understood, our aim was to determine the effect of extent and location of disease and prior resection and therapy on plasma DAO activity in Crohn's disease. Plasma postheparin DAO activity was significantly lower (17.4±3.0 vs 32.8±30.8 units/ml) and Crohn's disease activity index (178±105 vs 14±19,P<0.05) (CDAI) higher in 37 patients with CD compared to 30 normal volunteers. There was no overall correlation between DAO activity and CDAI. Effective medical or surgical therapy increased DAO activity and decreased CDAI, while clinical recurrence had the opposite effect. DAO activity was not related to the extent of small bowel disease (13.2±9.1; <30 cm, 18.5±11.8; 30–60 cm, and 5.7±6.4 units/ml; >60 cm) or colonic disease (13.0±6.9 segmental vs 24.0±15.4 units/ml, pancolitis). DAO activity was similar with small or large bowel disease (14.3±10.6 vs 18.8±13.1 units/ml). Prior enterectomy or colectomy did not significantly influence DAO activity. DAO activity responds predictably after effective therapy and recurrence and may prove useful in monitoring individual patients with CD. Failure of extent and location of disease and prior resection to influence DAO activity suggests that DAO activity is not directly related to enterocyte mass.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Shakir KMM, Margolis S, Baylin SB: Localization of histaminase (diamine oxidase) in rat small bowel intestinal mucosa: site of release by heparin. Biochem Pharmacol 26:2343–2347, 1977

    Google Scholar 

  2. Erdman SH, Park JHY, Thompson JS, Grandjean CJ, Hart MH, Vanderhoff SA: Suppression of diamine oxidase activity enhances post-resection ileal proliferation in the rat. Gastroenterology 96:1533–1538, 1989

    Google Scholar 

  3. D'Agostino L, Ciacci C, Capuano G, Daniele B, Barone MV, D'Argenio G, Rodino S, Budillon G, Mazzacca G: Metabolic fate of plasma diamine oxidase: Evidence of isolated and perfused rat liver uptake. Digestion 34:243–250, 1986

    Google Scholar 

  4. D'Agostino L, Daniele B, Pallone F, Pignata S, Leoni M, Mazzacca G: Postheparin diamine oxidase in patients with small bowel Crohn's disease. Gastroenterology 95:1503–1509, 1988

    Google Scholar 

  5. Luk GD, Bayless TM, Baylin SB: Plasma postheparin diamine oxidase: Sensitive provocative test for quantitating length of acute intestinal mucosal injury in the rat. J Clin Invest 71:308–315, 1983

    Google Scholar 

  6. White AR, Baylin SB, Olivecrona T, Beaven MA: Binding of diamine oxidase to rat and guinea pig microvascular endothelial cells. J Clin Invest 76:93–100, 1985

    Google Scholar 

  7. Daniele B, Quaroni A: Polarized secretion of dimaine oxidase by intestinal epithelial cells and its stimulation by heparin. Gastroenterology 99:1675–1697, 1990

    Google Scholar 

  8. Luk DG, Bayless TM, Baylin SB: Diamine oxidase: A circulating marker for rat intestinal mucosa maturation and integrity. J Clin Invest 66:66–70, 1980

    Google Scholar 

  9. D'Agostino L, Daniele B, Pignata S, Barone MV, Ciacci C, Sollazzo R, Mazzacca G: Postheparin plasma diamine oxidase increases in patients with celiac disease during gluten free diet. Gut 28(suppl):131–134, 1987

    Google Scholar 

  10. D'Agostino L, Ciacci C, Daniele B, Barone M, Sollazo R, Mazzacca G: Postheparin plasma diamine oxidase in subjects with small bowel mucosal atrophy. Dig Dis Sci 32:313–317, 1987

    Google Scholar 

  11. Forget P, Saye Z, Van Cutsem JL, Dandrifosse G: Serum diamine oxidase activity in acute gastroenteritis in children. Pediatr Res 19:26–28, 1985

    Google Scholar 

  12. Ely MJ, Speicher JM, Catravas CN, Snyder SL: Radiation effects on diamine oxidase activities in intestine and plasma of the rat. Radiati Res 103:158–162, 1985

    Google Scholar 

  13. Wollin A, Novert H, Bonnous G: Effect of intestinal ischemia on diamine oxidase activity in rat intestinal tissue and blood. Gastroenterology 80:349–355, 1981

    Google Scholar 

  14. Thompson JS, Burnett DA, Cormier RA, Vaughan WP: Plasma postheparin diamine oxidase: Development of a simple technique of assessing Crohn's disease. Dis Colon Rectum 31:529–532, 1988

    Google Scholar 

  15. Rokkas T, Vaja S, Murphy GM, Dowling RH: Postheparin plasma diamine oxidase (DAO): A non-invasive marker of active ileal Crohn's disease? Gut 27:A630, 1986

    Google Scholar 

  16. Rokkas T, Sashi V, Murphy GM, Dowling RH: Postheparin plasma diamine oxidase in health and intestinal disease. Gastroenterology 98:1493–1501, 1990

    Google Scholar 

  17. Thompson JS, Markin RS, Vaughan VP, Burnett DA: Intestinal mucosa diamine oxidase activity reflects intestinal involvement in Crohn's disease. Am J Gastroenterol 83:756–760, 1988

    Google Scholar 

  18. Schmidt WU, Sattler J, Hesterberg R, Roher HD, Zoedler T, Sitter H, Lorenz W: Human intestinal diamine oxidase (DAO) activity in Crohn's disease: A new marker for disease assessment? Agents Actions 30:267–270, 1990

    Google Scholar 

  19. Best WR, Becktel JM, Singleton JW, Kern FJ: Development of a Crohn's disease activity index: Natural Cooperative Crohn's Disease Study. Gastroenterology 70:439–444, 1976

    Google Scholar 

  20. Prantera C, Luzi C, Olivotto P, Levenstein S, Cerro P, Fanucci A: Relationship between clinical and laboratory parameters and length of lesion in Crohn's disease of small bowel. Dig Dis Sci 29:1093–1097, 1984

    Google Scholar 

  21. Wright SP, Young GO, Tigler-Wybrandi N: Predictors of acute relapse of Crohn's disease: A laboratory and clinical study. Dig Dis Sci 32:164–170, 1987

    Google Scholar 

  22. Gomes P, Boulay CD, Smith CL, Holdstock G: Relationship between disease activity indices and colonoscopic findings in patients with colonic inflammatory bowel disease. Gut 27:92–95, 1986

    Google Scholar 

  23. Saverymuttu SH, Camilleri M, Rees H, Lavender JP, Hodgson HJF, Chadwick VA: Indium-111 granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. Gastroenterology 90:1121–1128, 1986

    Google Scholar 

  24. Goldberg HI, Caruthers SB, Nelson JA, Singleton JW: Radiographic findings of the National Cooperative Crohn's Disease Study. Gastroenterology 77:925–937, 1979

    Google Scholar 

  25. D'Agostino L, Daniele B, Pignata S, Greco L, Mazzacca G; Postheparin plasma diamine oxidase in subjects with small bowel disease: Diagnostic efficiency of a simplified test. Digestion 41:46–54, 1988

    Google Scholar 

  26. Baylin SB, Beaver MA, Krauss RM, Keiser HR: Response of plasma histaminase activity to small doses of heparin in normal subjects and patients with hyperlipoproteinemia. J Clin Invest 52:1985–1993, 1973

    Google Scholar 

  27. Corazza GR, Falasca A, Strocchi A, Rossi CA, Gasbarrini G: Decreased plasma postheparin diamine oxidase levels in celiac disease. Dig Dis Sci 33:956–961, 1988

    Google Scholar 

  28. Sattler J, Hesterberg R, Lorenz W, Schmidt V, Crombach M, Stahlknecht CD: Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: Relevance for clinical side effect. Agents Actions 16:91–94, 1985

    Google Scholar 

  29. Knutson L, Ahrenstedt D, Odlind B, Hallgren R: The jejunal secretion of histamine is increased in active Crohn's Disease. Gastroenterology 98:849–854, 1990

    Google Scholar 

  30. Thompson JS: The significance of the intestinal gradient of diamine oxidase activity. Dig Dis 8:163–168, 1990

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, University of Nebraska Medical Center, 600 S. 42nd St., 68198-3280, Omaha, Nebraska

    Jon S. Thompson MD, David A. Burnett MD & William P. Vaughan MD

  2. Department of Medicine, University of Nebraska Medical Center, Omaha, USA

    Jon S. Thompson MD, David A. Burnett MD & William P. Vaughan MD

  3. the Omaha VAMC and Creighton, University School of Medicine, Omaha, USA

    Jon S. Thompson MD, David A. Burnett MD & William P. Vaughan MD

Authors
  1. Jon S. Thompson MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David A. Burnett MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. William P. Vaughan MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by a grant from the National Foundation of Ileitis and Colitis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thompson, J.S., Burnett, D.A. & Vaughan, W.P. Factors affecting plasma postheparin diamine oxidase activity. Digest Dis Sci 36, 1582–1588 (1991). https://doi.org/10.1007/BF01296401

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01296401

Key Words

Search

Navigation