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Stimulation of gastrointestinal motility by loperamide in dogs

Digestive Diseases and Sciences volume 32, pages 641–646 (1987)Cite this article

Abstract

The effects of loperamide on gastrointestinal motility were investigated in conscious fasted dogs chronically fitted with strain-gauge transducers on the antrum, the jejunum, and the colon. Oral administration of loperamide (0.1 mg/kg) induced, after a delay of 20–30 min, a long-lasting (8–12 hr) stimulation of gastrointestinal motility associated with a disorganization of the cyclic activity at the three levels investigated. These effects were reproduced by a subcutaneous administration at the same dose and were antagonized by previous intravenous administration of naloxone or a quaternary opiate antagonist. Intracolonic administration (0.1 mg/kg) stimulated, after a delay of 20–30 min, colonic motility only. Intracerebroventricular loperamide (1 μg/kg) induced a long-lasting (15–20 hr) inhibition of the gastric motility and a short (2-hr) disorganization of the jejunal motor profile. These data show that oral loperamide stimulates gastrointestinal motility in dogs and involves peripheral opiate receptors.

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Authors and Affiliations

  1. Department of Pharmacology, INRA, Toulouse, France

    Jean Fioramonti DS, Marie-Jose Fargeas BS & Lionel Bueno DS

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  1. Jean Fioramonti DS
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  2. Marie-Jose Fargeas BS
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  3. Lionel Bueno DS
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Fioramonti, J., Fargeas, MJ. & Bueno, L. Stimulation of gastrointestinal motility by loperamide in dogs. Digest Dis Sci 32, 641–646 (1987). https://doi.org/10.1007/BF01296165

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  • DOI: https://doi.org/10.1007/BF01296165

Key Words

  • gastrointestinal motility
  • opiates
  • loperamide
  • dog