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Stimulation of gastrointestinal motility by loperamide in dogs

Abstract

The effects of loperamide on gastrointestinal motility were investigated in conscious fasted dogs chronically fitted with strain-gauge transducers on the antrum, the jejunum, and the colon. Oral administration of loperamide (0.1 mg/kg) induced, after a delay of 20–30 min, a long-lasting (8–12 hr) stimulation of gastrointestinal motility associated with a disorganization of the cyclic activity at the three levels investigated. These effects were reproduced by a subcutaneous administration at the same dose and were antagonized by previous intravenous administration of naloxone or a quaternary opiate antagonist. Intracolonic administration (0.1 mg/kg) stimulated, after a delay of 20–30 min, colonic motility only. Intracerebroventricular loperamide (1 μg/kg) induced a long-lasting (15–20 hr) inhibition of the gastric motility and a short (2-hr) disorganization of the jejunal motor profile. These data show that oral loperamide stimulates gastrointestinal motility in dogs and involves peripheral opiate receptors.

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Fioramonti, J., Fargeas, MJ. & Bueno, L. Stimulation of gastrointestinal motility by loperamide in dogs. Digest Dis Sci 32, 641–646 (1987). https://doi.org/10.1007/BF01296165

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  • DOI: https://doi.org/10.1007/BF01296165

Key Words

  • gastrointestinal motility
  • opiates
  • loperamide
  • dog