Abstract
This study investigates release of somatostatin-like immunoreactivity (SLI) into the gastric lumen of five healthy human subjects in response to pharmacological stimuli (pentagastrin and secretin) and physiological stimuli (sham feeding and intrajejunal perfusion of elemental diet). Basal and poststimulation gastric juice aspirates were collected at 15-min intervals, extracted with acetone, and SLI determined by radioimmunoassay, with these results: (1) A considerable amount of SLI was secreted during the basal period. (2) Pentagastrin stimulated SLI release quickly and was associated with increased acid secretion. (3) Both secretin and sham feeding increased SLI only slightly. (4) During intrajejunal perfusion of the elemental diet, SLI increased significantly, was associated with decreased acid secretion, and rapidly returned to basal level when elemental diet was replaced by saline. Basal levels of gastric luminal SLI thus showed distinct changes in response to each stimulus. Although the physiological action of luminal SLI remains to be studied, its levels may reflect gastric D-cell activities.
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References
Larsson LI, Goltermann KN, De Magistris L, Rehfeld JR, Schwartz TS: Somatostatin cell processes as pathway for paracrine secretion. Science 205:1391–1395, 1979
Larsson LI: Gastrointestinal cells producing endocrine, neurocrine and paracrine messenger. Clin Gastroenterol 9:485–516, 1980
Reichlin S: Somatostatin. N Engl J Med 309:1495–1501, 1556–1563, 1983
Uvnas-Wallensten K, Efendic S, Luft R: Vagal release of somatostatin into the antral lumen of cats. Acta Physiol Scand 99:126–128, 1977
Uvnas-Wallensten K: Vagal release of antral hormones.In Gut Hormones. SR Bloom (ed). Edinburgh, Churchill-Livingstone, 1978, pp 389–393
Uvnas-Wallensten K: Release of substance P into the antral lumen of cats. Acta Physiol Scand 104:464–468, 1978
Uvnas-Wallensten K, Efendic S, Luft R: Release of somatostatin into the antral lumen of cats. Proceedings from the International Symposium on Somatostatin. Metabolism 27(Suppl 1):1233–1234, 1978
Arnold R, Lankisch P: Somatostatin and the gastrointestinal tract. Clin Gastroenterol 9:733–753, 1980
Wisen O, Uvnas-Wallensten K, Efendic S, Johansson C: Release of gastrin and somatostatin into the gastric lumen of healthy subjects and patients with duodenal ulcer and achlorhydria. Acta Physiol Scand 108:297–300, 1980
Feldman M, Richardson CT, Fordtran JS: Experience with sham feeding as a test for vagotomy. Gastroenterology 79:792–795, 1980
Ertan A, Brooks FP, Arvan D, Williams CN: Mechanism of release of endogenous cholecystokinin by jejunal amino acid perfusion in man. Am J Dig Dis 20:813–823, 1975
Arimura A: Radioimmunoassay for somatostatin in tissue and blood.In Gastrointestinal Hormones. GBJ Glass (ed). New York, Raven Press, 1980, pp 841–854
Dixon WJ: BMDP Statistical Software. Berkeley, University of California Press, 1981, pp 366–369
Uvnas-Wallensten K: Luminal secretion of gut peptides. Clin Gastroenterol 9:545–553, 1980
Johansson C, Wisen O, Kollberg B, Efendic S, Uvnas-Wallensten K: Effects of intragastrically administered somatostatin on the basal and pentagastrin stimulated gastric secretion in man. Acta Physiol Scand 104:232–234, 1979
Fiddian-Green RG, Pittenger G, Kothary P: Effect of luminal somatostatin on acid secretion and gastrin release. Scand J Gastroenterol 15:305–309, 1980
Chiba T, Taminato T, Kadowaki S, Inoue Y, Mori K, Senio Y, Abe H, Chihara K, Matsukura S, Fujita T, Goto Y: Effect of various gastrointestinal peptides on gastric somatostatin release. Endocrinology 106:145–149, 1980
Schusdziarra V, Rouiller D, Harris V, Conlon M, Unger RH: The response of plasma somatostatin-like immunoreactivity to nutrients in normal and alloxan-diabetic dogs. Endocrinology 103:2264–2273, 1978
Schusdziarra V, Rouiller D, Harris V, Unger RH: Gastric and pancreatic release of somatostatin-like immunoreactivity during the gastric phase of a meal: Effects of truncal vagotomy and atropine in the anesthetized dog. Diabetes 28:658–663, 1979
Schusdziarra V, Rouiller D, Pietri A, Harris V, Zyznar E, Conlon JM, Unger RH: Pancreatic and gastric release of somatostatin-like immunoreactivity during the intestinal phase of a meal. Am J Physiol 237:555–560, 1979
Schuzdziarra V: Somatostatin-A regulatory modulator connecting nutrient entry and metabolism. Horn Metab Res 12:563–577, 1980
Malagelada JR: Gastric, pancreatic and biliary responses to a meal.In Physiology of the Gastrointestinal Tract. LR Johnson (ed). New York, Raven Press, 1981, pp 893–924
Grossman MI: The gastrointestinal hormones: An overview.In Endocrinology, Vol. 2. VHT James (ed). Amsterdam, Excerpta Medica, 1976, pp 1–6
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This study was supported by the Gastroenterology Section Research Fund 530569.
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Degertekin, H., Ertan, A., Akdamar, K. et al. Luminal gastric somatostatin-like immunoreactivity in response to various stimuli in man. Digest Dis Sci 31, 833–839 (1986). https://doi.org/10.1007/BF01296052
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DOI: https://doi.org/10.1007/BF01296052