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Cisapride offsets dopamine-induced slowing of fasting gastric emptying

Digestive Diseases and Sciences volume 31, pages 807–810 (1986)Cite this article

Abstract

The effect of cisapride, a new gastrokinetic drug, on gastroduodenal motility was tested in six healthy volunteers. In order to obtain a model for slowed gastric emptying, dopamine was infused at a rate of 8 μg/kg/min. Dopamine significantly slowed the fractional emptying rate of fasting gastric contents from 5.14±0.37 to 1.45±0.67%/min. Injection of either 10 mg of cisapride or 10 mg of metoclopramide restored emptying rate to normal (5.87±0.56 and 5.62±0.61%/min, respectively). When cisapride was given without dopamine background, emptying was only moderately enhanced. Reflux of bile salts was not significantly affected by either cisapride or dopamine alone. When given on a dopamine background, however, both metoclopramide and cisapride decreased bile salt reflux below control values without any active treatment. It is concluded that emptying of fasting gastric contents can be speeded by cisapride, particularly when emptying is slowed by dopamine. A clear effect on bile salt reflux cannot be demonstrated.

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References

  1. Connell AM, George JD: Effect of metoclopramide on gastric function in man. Gut 10:678–680, 1969

    Google Scholar 

  2. Hancock BD, Bowen-Jones E, Dixon R, Dymock IW, Cowley DJ: The effect of metoclopramide on gastric emptying of solid meals. Gut 15:462–467, 1974

    Google Scholar 

  3. McCallum RW, Fink SM, Lerner E, Berkowitz DM: Effects of metoclopramide and bethanechol on delayed gastric emptying present in gastroesophageal reflux patients. Gastroenterology 84:1573–1577, 1983

    Google Scholar 

  4. Metzger WH, Cano R, Sturdevant RAL: Effect of metoclopramide in chronic gastric retention after gastric surgery. Gastroenterology 71:30–32, 1976

    Google Scholar 

  5. Berkowitz DM, McCallum RW: The effect ofl-dopa on gastric emptying in man. Clin Res 25:569, 1977

    Google Scholar 

  6. Valenzuela JE: Dopamine as a possible neurotransmitter in gastric relaxation. Gastroenterology 71:1019–1022, 1976

    Google Scholar 

  7. Pfeuffer-Friedrich I, Kilbinger H: Facilitation and inhibition by 5-hydroxytryptamine and R 51619 of acetylcholine release from guinea pig myenteric neurones.In Gastrointestinal Motility. C Roman (ed). Lancaster, MTP Press, 1984, pp 527–534

    Google Scholar 

  8. Schulze-Delrieu K: Metoclopramide. Gastroenterology 77:768–779, 1979

    Google Scholar 

  9. van Nueten JM, Van Daele FGH, Reyntjens AJ, Janssen PAJ, Schuurkes JAJ: Gastrointestinal motility stimulating properties of cisapride, a noncholinergic compound.In Gastrointestinal Motility. C Roman (ed). Lancaster, MTP Press, 1984, pp 513–520

    Google Scholar 

  10. Jacoby HI, Brodie DA: Gastrointestinal actions of metoclopramide. An experimental study. Gastroenterology 52:676–684, 1967

    Google Scholar 

  11. Buxton TB, Crockett JK, Moore WL Jr, Rissing JP: Protein precipitation by acetone for the analysis of polyethylene glycol in intestinal perfusion fluid. Gastroenterology 76:820–824, 1979

    Google Scholar 

  12. Talalay P: Enzymatic analysis of steroid hormones. Methods Biochem Anal 8:119–143, 1960

    Google Scholar 

  13. Müller-Lissner SA, Fimmel CJ, Sonnenberg A, Will N, Müller-Duysing W, Heinzel F, Müller R, Blum AL: A novel approach to quantify duodenogastric reflux in healthy volunteers and in type I gastric ulcer. Gut 24:510–518, 1983

    Google Scholar 

  14. Wissenschaftliche Tabellen Geigy, 8th ed. Basel, 1982

  15. Caldara R, Ferrari C, Romussi M, Bierti L, Gandini S, Curtarelli G: Effect of dopamine infusion on gastric and pancreatic secretion and gastrin release in man. Gut 19:724–728, 1978

    Google Scholar 

  16. Hovendal CP, Bech K, Gottrup F, Andersen D: Effect of dopamine on pentagastrin-stimulated gastric acid secretion and mucosal blood flow in dogs with gastric fistula. Scand J Gastroenterol 17:97–102, 1982

    Google Scholar 

  17. Bech K, Hovendal CP: Effect of dopamine on pentagastrin-stimulated gastric antral motility in dogs with gastric fistula. Scand J Gastroenterol 17:103–107, 1982

    Google Scholar 

  18. Bech K, Hovendal CP: Effect of dopamine on bethanechol-stimulated gastric antral motility in dogs with gastric fistula. Scand J Gastroenterol 17:945–951, 1982

    Google Scholar 

  19. Van Nueten JM, Schuurkes JAJ: Stimulating effects of cisapride on isolated preparations of stomach, small and large intestine of the guinea pig. Gastroenterology 86:1288, 1984 (abstract)

    Google Scholar 

  20. Ramsbottom N, Hunt JN: Studies of the effect of metoclopramide and apomorphine on gastric emptying and secretion in man. Gut 11:989–993, 1970

    Google Scholar 

  21. Jian R, Ducrot F, Piedeloup C, Mary JY, Najean Y, Bernier JJ: Measurement of gastric emptying in dyspeptic patients; effect of a new gastrokinetic agent (cisapride). Gut 26:352–358, 1985

    Google Scholar 

  22. Müller-Lissner SA, Fraass C: Dissociation of duodenogastric marker reflux and bile salt reflux. Dig Dis Sci 30:733–738, 1985

    Google Scholar 

  23. Rhodes J, Barnardo DE, Phillips SF, Rovelstad RA, Hofmann AF: Increased reflux of bile into the stomach in patients with gastric ulcer. Gastroenterology 57:241–252, 1969

    Google Scholar 

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Affiliations

  1. Department of Gastroenterology, Medizinische Klinik Innenstadt, University of Munich, Ziemssenstr. 1, D-8000, München 2, Germany

    Stefan A. Müller-Lissner, Christine Fraas & Anton Härtl

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  1. Stefan A. Müller-Lissner
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  2. Christine Fraas
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  3. Anton Härtl
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Müller-Lissner, S.A., Fraas, C. & Härtl, A. Cisapride offsets dopamine-induced slowing of fasting gastric emptying. Digest Dis Sci 31, 807–810 (1986). https://doi.org/10.1007/BF01296047

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  • DOI: https://doi.org/10.1007/BF01296047

Keywords

  • Public Health
  • Dopamine
  • Healthy Volunteer
  • Active Treatment
  • Gastric Emptying