Abstract
Fourteen patients with duodenal ulcers and eight healthy volunteers were examined to measure interdigestive gastroduodenal motility and plasma motilin. In order to study the effects of gastric acid on the gastroduodenal motility, 20 mg of famotidine was administered intravenously. The motility index of the gastric antrum and the duodenum, as well as the pH in the duodenal bulb were calculated. The duodenal pH was significantly lower and the gastric motility index was significantly weaker before the duodenal interdigestive migrating complex (IMC) in the ulcer patients than in the controls. Motilin levels increased before the duodenal IMC and decreased afterwards in both groups. Famotidine significantly increased the duodenal pH and the gastric motility index before the IMC, but no changes in the motilin level were noted. We conclude that duodenal ulcer patients have duodenal hyperacidity that results from increased inflow from the antrum and antral hypomotility during the gastric IMC and that these changes are normalized by the administration of famotidine. These results suggest that gastric acid inhibits antral contraction during the gastric IMC.
Similar content being viewed by others
References
Griffith GH, Owen GM, Kirkman S, Shields R: Measurement of rate of gastric emptying using chromium-51. Lancet 1:1244–1245, 1966
Heading RC, Tothill P, McLoughlin GP, Shearman DJC: Gastric emptying rate measurement in man. Gastroenterology 71:45–50, 1976
Harasawa S, Tani N, Suzuki S, Miwa M, Sakita R, Nomiyama T, Miwa T: Gastric emptying in normal subjects and patients with peptic ulcer. A study using the acetaminophen method. Gastroenterologia Jpn 14:1–10, 1979
Lam SK, Isenberg JI, Grossman MI, Lane WH, Hogan DL: Rapid gastric emptying in duodenal ulcer patients. Dig Dis Sci 27:598–604, 1982
Code CF, Marlett JA: The interdigestive myoelectric complex of the stomach and small bowel of dogs. J Physiol 246:289–309, 1975
Sekiguchi T, Nishioka T, Kogure M, Sugiyama M, Fukagawa H, Kobayashi S: Difference of interdigestive gastroduodenal motility and duodenal pH between duodenal and gastric ulcer patients. Jpn J Smooth Muscle Res 21(suppl):113–124, 1985
Hansen WE, Bertl S: Inhibition of acetylcholinesterases—a relevant side-effect of ranitidine? Z Gastroenterol 21:164–167, 1983
Bertaccini G, Coruzzi G: Cholinergic-like effects of the new histamine H2-receptor antagonist ranitidine. Agents Action 12:167–171, 1982
Jensen JG, Gugler R: Relevante Hemmung der Acetylcholinesterase durch H2-Rezeptorantagonisten? Z Gastroenterol 22:109–112, 1984
Yanaihara C, Sato H, Yanaihara N, Naruse S, Forssmann WG, Helmstaedter V, Fujita T, Yamaguchi K, Abe K: Motilin-, substance P- and somatostatin-like immunoreactivities in extracts from dog, tupaia and monkey brain and GI tract.In Gastrointestinal Hormones and Pathology of the Digestive System. M Grossman, V Speranza, N Basso, E Lezoche (eds). New York, Plenum Publishing, 1978, pp 269–283
Shima K, Shin S, Tanaka A, Hashimura E, Nishino T, Imagawa K, Kumahara Y, Yanaihara N: Heterogeneity of plasma motilin in patients with chronic renal failure. Horm Metab Res 12:328–331, 1980
Hutson WR, Roehrkasse RL, Wald A: Influence of gender and menopause on gastric emptying and motility. Gastroenterology 96:11–17, 1989
Aono M, Moriga M, Mizuta K, Narusawa H: Cholinergic effects of histamine-H2 receptor antagonists partly through inhibition of acetylcholinesterase. Gastroenterol Jpn 21:213–219, 1986
Takagi T, Takeda M, Maeno H: Effect of a new potent H2-blocker, 3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]-thio]-N3-sulfamoylpropionamidine (YM-11170) on gastric secretion induced by histamine and food in conscious dogs. Arch Int Pharmacodyn 256:49–58, 1982
Lewis TD, Collins SM, Fox JE, Daniel EE: Initiation of duodenal acid-induced motor complexes. Gastroenterology 77:1217–1224, 1979
Allescher H-D, Daniel EE, Dent J, Fox JET, Kostolanska F: Neural reflex of the canine pylorus to intraduodenal acid infusion. Gastroenterology 96:18–28, 1989
Hayashi N, Mizumoto A, Kusano M, Sekiguchi T, Itoh Z: Inhibition of gastric acid secretion by H2 receptor antagonist normalizes interdigestive motor cycle in the stomach in dog and man. Gastroenterology 98:A56, 1990 (abstract)
Okajima M: Role of endogenous histamine in the control mechanism of postprandial gastric motility in dogs. Hiroshima Univ Med J 36:733–750, 1988
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kusano, M., Sekiguchi, T., Nishioka, T. et al. Gastric acid inhibits antral phase III activity in duodenal ulcer patients. Digest Dis Sci 38, 824–831 (1993). https://doi.org/10.1007/BF01295907
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01295907