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Gastric acid inhibits antral phase III activity in duodenal ulcer patients

Digestive Diseases and Sciences volume 38, pages 824–831 (1993)Cite this article

Abstract

Fourteen patients with duodenal ulcers and eight healthy volunteers were examined to measure interdigestive gastroduodenal motility and plasma motilin. In order to study the effects of gastric acid on the gastroduodenal motility, 20 mg of famotidine was administered intravenously. The motility index of the gastric antrum and the duodenum, as well as the pH in the duodenal bulb were calculated. The duodenal pH was significantly lower and the gastric motility index was significantly weaker before the duodenal interdigestive migrating complex (IMC) in the ulcer patients than in the controls. Motilin levels increased before the duodenal IMC and decreased afterwards in both groups. Famotidine significantly increased the duodenal pH and the gastric motility index before the IMC, but no changes in the motilin level were noted. We conclude that duodenal ulcer patients have duodenal hyperacidity that results from increased inflow from the antrum and antral hypomotility during the gastric IMC and that these changes are normalized by the administration of famotidine. These results suggest that gastric acid inhibits antral contraction during the gastric IMC.

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Affiliations

  1. First Department of Internal Medicine, Gunma University, School of Medicine, 3-39-15 Showamachi Maebashi, 371, Gunma, Japan

    Motoyasu Kusano MD, Toshikazu Sekiguchi MD, Toshio Nishioka MD, Osamu Kawamura MD, Kazuma Kikuchi MD, Tsutomu Matsuzaki MD & Tsutomu Horikoshi MD

Authors
  1. Motoyasu Kusano MD
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  2. Toshikazu Sekiguchi MD
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  3. Toshio Nishioka MD
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  4. Osamu Kawamura MD
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  5. Kazuma Kikuchi MD
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  6. Tsutomu Matsuzaki MD
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  7. Tsutomu Horikoshi MD
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Kusano, M., Sekiguchi, T., Nishioka, T. et al. Gastric acid inhibits antral phase III activity in duodenal ulcer patients. Digest Dis Sci 38, 824–831 (1993). https://doi.org/10.1007/BF01295907

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  • DOI: https://doi.org/10.1007/BF01295907

Key Words

  • gastroduodenal motility
  • motilin
  • famotidine
  • duodenal ulcer
  • gastric acid
  • interdigestive migrating complex