Summary
Male Sprague-Dawley rats were treated for 7 days with the norepinephrine (NE) uptake inhibitors desipramine (DMI) or (+)-oxaprotiline or the inactive (−)-enantiomer of oxaprotiline. DMI, as previously reported, significantly increased hippocampal glucocorticoid receptor (GR) mRNA while the equipotent NE uptake inhibitor (+)-oxaprotiline like the inactive (−)-oxaprotiline did not alter hippocampal levels of GR mRNA. The results indicate that an increase in the synaptic availability of NE as a consequence of uptake inhibition is not responsible for the action of DMI on GR gene expression.
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Eiring, A., Sulser, F. Increased synaptic availability of norepinephrine following desipramine is not essential for increases in GR mRNA. J. Neural Transmission 104, 1255–1258 (1997). https://doi.org/10.1007/BF01294725
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DOI: https://doi.org/10.1007/BF01294725