Summary
A tracer kinetic method is outlined for the treatment of multicompartmental non steady-state systems. Metabolic rates are considered as consisting of two components: one of them (exchange) is balanced by a reverse process of the same rate, and the other (transport) results in concentration change. Assuming the transport rates to be known, the method allows of excluding a lot of logically possible compartmental models as inconsistent with the experimental data. Thus the real compartment structure of the system can be approached.
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Fajszi, C., Latzkovits, L. Contributions to the treatment of tracer distribution equations in multicompartmental systems. Biophysik 9, 64–69 (1972). https://doi.org/10.1007/BF01293480
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DOI: https://doi.org/10.1007/BF01293480