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COPI proteins: A model for their role in vesicle budding

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Summary

COPI-coated vesicles are involved in intracellular trafficking between the endoplasmic reticulum and the Golgi complex. In the current model for COPI assembly the small GTP-binding protein ADP-ribosylation factor 1 is recruited from the cytoplasm to the Golgi membrane followed by binding of the hetero-oligomeric protein complex coatomer. However, the mechanism of subsequent vesicle budding is discussed controversially. This review summarizes the available experimental data on the COPI coat and discusses a model of how the major coat protein, coatomer, might act in vesicle budding.

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  1. Biochemie-Zentrum Heidelberg, Ruprecht-Karls-Universität, Im Neuenheimer Feld 328, D-69120, Heidelberg, Germany

    C. Harter

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Harter, C. COPI proteins: A model for their role in vesicle budding. Protoplasma 207, 125–132 (1999). https://doi.org/10.1007/BF01282991

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