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Mitochondrial complex I: new insights from inhibitor assays

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Summary

The NADH:ubiquinone oxidoreductase (complex I) of the mitochondrial respiratory chain is by far the most complicated of the proton-translocating enzymes involved in the oxidative phosphorylation. Many clues regarding both electron transfer and proton translocation are still unknown. In this sense, inhibitor assays are relevant and useful pieces for elaborating a suitable model to explain the elusive bioenergetic mechanism of this enzyme. This short review presents the most recent advances in inhibitor studies and highlights the major controversies.

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Abbreviations

ACG:

annonaceous acetogenin

MPP+ :

methylphenyl-pyridinium

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Authors and Affiliations

  1. Departament de Bioquímica i Biologia Molecular, Facultat de Farmàcia, Universitat de València, Avenguida Vicent Estellés s/n, E-46100, Burjassot, Spain

    E. Estornell

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Estornell, E. Mitochondrial complex I: new insights from inhibitor assays. Protoplasma 213, 11–17 (2000). https://doi.org/10.1007/BF01280500

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  • DOI: https://doi.org/10.1007/BF01280500

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