Abstract
Indium-111-labelled platelet scintigraphy was performed in two patients after laser-assisted balloon angioplasty. Both patients demonstrated a significant ‘hot spot’ at the angioplasty site 24 h after successful recanalisation with laser and balloon. Clinically apparent thrombosis of the recanalised arteries occurred 5 and 6 days after angioplasty in both patients. Laser-assisted balloon angioplasty leads to significant platelet deposition over recanalised segments of the artery,. which may result in arterial thrombosis, as evident from the reports presented. Indium-111-labelled platelet scintigraphy emphasises the extent of trauma caused by laser and balloon angioplasty to the arterial wall.
References
Abela GS, Crea F, Smith W, Pepine CJ, Conti R (1985) In vitro effects of argon laser radiation on blood: quantitative and morphologic analysis. J Am Coll Cardiol 5:231–237
Block PC, Myler RK, Stertzer S, Fallon JT (1981) Morphology after transluminal angioplasty in human beings. N Engl J Med 5(7):382–385
Cumberland DC, Sanborn TA, Taylor DI, Moore DJ, Welsh CL, Greenfield AJ, Guben JK, Ryan TJ (1986) Percutaneous laser thermal angioplasty: initial clinical results with a laser thermal probe in total peripheral arterial occlusions. Lancet 1:1457–1459
Doerger PT, Glueck HI, Bel-Khan J van der, Tayloe A, Goldman L (1985) The comparative effects of argon, Nd:YAG and argon-pumped dye lasers on human platelets and erythrocytes in vitro. Lasers Surg Med 5:457–468
Doerger PT, Glueck HI, McGill M (1988) The effects of argon laser on in vitro aggregation of platelets in platelet rich plasma and whole blood. Thromb Res 50:657–667
Eldar M, Gal D, Djaldetti M, Douer D, Rosner E, Katzir A, Neufeld HN, Battler A (1988) Carbon dioxide laser effect on platelet function and surface ultrastructure in vitro. Lasers Surg Med 8:259–263
Enge IP, Schilvold A (1988) Recanalisation of occluded peripheral vessels by laser assisted PTA. Ann Radiol (Paris) 31(2):74–76
Gardiner GA, Meyerovitz MF, Stokes KR, Clouse ME, Harrington DP, Bettman MA (1986) Complications of transluminal angioplasty. Radiology 159:201–208
Geschwind HJ, Kern MJ, Vandormael MG, Blair JD, Deligonul U, Kennedy HL (1987) Efficiency and safety of optically modified fibre tips for laser angioplasty. J Am Coll Cardiol 10:655–661
Hawker RJ, Wilkinson AR, Hawker LM (1980) Indium (111 In) labelled human platelets: optimal methods. Clin Sci 58:243–248
Kaplan KL, Owen J (1986) Plasma levels of platelet secretory proteins. CRC Crit Rev Oncol Haematol 5(3):235–254
Lam JYT, Chesbro JH, Steele PM, Dewanjee MK, Badimon L, Fuster V, Byrne JM, Lamb HB, Wendlang BI (1986) Deep arterial injury during experimental angioplasty: relation to a positive indium 111 labeled platelet scintigram, quantitative platelet deposition and mural thrombosis. J Am Coll Cardiol 8:1380–1386
Lammer J, Karnel F (1988) Percutaneous transluminal laser angioplasty with contact probes. Radiology 168:733–737
Minar E, Ehringer H, Ahmadi R, Dudczak R, Leitha T, Koppensteiner R, Jung M, Stumpften A (1989) Platelet deposition at angioplasty sites and its relation to restenosis in human iliac and femoropopliteal arteries. Radiology 170:767–772
Morley D, Santamore AT (1988) An in vitro model of platelet aggregation in stenotic arteries. J Pharmacol Methods 19:319–338
Pasternack RC, Baughman KL, Fallon JT, Block PC (1979) Scanning electron microscopy after coronory transluminal angioplasty of normal canine coronory arteries. Am J Cardiol 45:591–598
Pope CF, Ezekowitz MD, Smith ED, Rapoport S, Glickman M, Sostman D, Zaret BL (1985) Detection of platelet deposition at the site of peripheral balloon angioplasty using indium 111 platelet scintigraphy. Am J Cardiol 55:495–497
Sanborn TA, Haudenschild CC, Garber GR, Ryan TR, Faxon DP (1987) Angiographic and histologic consequences of laser thermal angioplasty: comparison with balloon angioplasty. Circulation 75(6):1281–1286
Sanborn TA, Cumberland DC, Greenfield AJ, Welsh CL, Guben JK (1988) Percutaneous laser thermal angioplasty: initial results and 1-year follow-up in 129 femoropopliteal lesions. Radiology 168:121–125
Sevitt S (1986) Platelets and foam cells in the evolution of atherosclerosis. Histological and immunohistological studies of human lesions. Atherosclerosis 61:107–115
White RA, White GH (1989) Laser thermal probe recanalisation of occluded arteries. J Vasc Surg 9:594–604
Wilentz JR, Sanborn TA, Haudenschild CC, Valeri CR, Ryan TJ, Faxon DP (1987) Platelet accumulation in experimental angioplasty: time course and relation to vascular injury. Circulation 75(3):636–642
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Mohan, S.R., Hawker, R.J., Wolinski, A.P. et al. Detection of arterial thrombosis after laser angioplasty by platelet scintigraphy. Eur J Nucl Med 16, 865–868 (1990). https://doi.org/10.1007/BF01280253
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DOI: https://doi.org/10.1007/BF01280253