Abstract
Eleven patients with proven primary bone tumour (five Ewing sarcomas, six osteosarcomas) and two cases of metastatic bone involvement (primary other than bone) were investigated with99mTc-phytate and99mTc-sulphur colloid to compare the behaviour of the two radiopharmaceuticals at the tumour site. After intravenous administration of the respective radiopharmaceutical, imaging of the tumour site and its contralateral part was carried out at 15 min and 1 h intervals. The data were stored in our computer. Bone scanning was also carried out in all patients.99mTc-phytate uptake was observed at the tumour site in ten cases. The99mTc-sulphur colloid study revealed sparse or no significant uptake in eight cases. In two patients, with osteosarcoma99mTc-sulphur colloid investigation showed uptake at the primary tumour site. However, the distribution pattern is different from that of99mTc-phytate. No significant uptake of either 99mTc-phytate or99mTc-sulphur colloid was observed in the two patients with metastatic skeletal disease. It may be concluded that the unusual accumulation of99mTc-phytate at the tumour site is not due to any generalized reticuloendothelial phenomenon and that the radiopharmaceutical itself is responsible for this.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chew FS, Hudson TM (1982) Radionuclide bone scanning of osteosarcoma: falsely extended uptake patterns. AJR 139:40
David Charkes N (1979) Mechanism of skeletal tracer uptake. J Nucl Med 20:794
Davies NT, Nightingale R (1975) The effect of phytate on intestinal absorption and secretion of zinc and whole body retention of zinc, copper and manganese in rats. Br J Nutr 34:243
Davis MA, Kaplan ML, Ahnberg DS, Cole CN (1977) A modified99mTc-phytate colloid for liver-spleen imaging. Int J Appl Radiat Isot 28:123
Eckelman WC, Levenson SM (1977) Radiopharmaceuticals labelled with technetium. Int J Appl Radiat Isot 28:67
Frankel RS, Jones AE, Cohen JA, et al. (1974) Clinical correlation of Ga-67 and skeletal whole-body radionuclide studies with radiography in Ewing's sarcoma. Radiology 110:597
Hiroaki Hoshi, Seishi Jinnouchi, Masahiko Sameshima, Osamu Uwada and Katsushi Watanabe. Tc-99m Hexamethylpropylene-amine oxine (HM-PAO) uptake in a bone metastasis. Clin Nucl Med 13:595
Jones AG, Francis MD, Davis MA (1976) Bone scanning: radionuclide reaction mechanism. Semin Nucl Med 6:3
Nageswara Rao P, Sumathi NM, Devaru S, Krishna Bhargava M, Nagaiah HJ (1989) Uptake of99mTc-phytate in osteosarcoma cases. Eur J Nucl Med 15:162
Noronha OPD (1986) In-house production and control of a few99mTc-radiopharmaceuticals. Int J Appl Radiat Isot 37:1150
Oberleas D (1973) Phytates. Intoxicants occurring naturally in foods. National Academy of Sciences, Washington, DC, p 363
Subramanian G, McAfee JG, Mehter A (1973)99mTc-stannous phytate - a new in-vivo colloid for imaging the reticuloendothelial system. J Nucl Med 14:459
Subramanian G, McAfee JG, Blair RJ, Thomas FD (1975)99mTc-labelled phosphate compounds in nuclear medicine. In: Nuklearmedizin in klinischer and technologischer Sicht: Zwblfte Jahrestagung der Gesellschaft für Nuklearmedizin. Schattauer, Munich Stuttgart, p 790
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rao, P.N., Murthy, S.N., Muddukrishna, S.N. et al. Comparison of technetium 99m-phytate and technetium 99m-sulphur colloid in primary bone tumours. Eur J Nucl Med 16, 847–853 (1990). https://doi.org/10.1007/BF01280249
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01280249