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Caves and labyrinths: caveolae and transverse tubules in skeletal muscle

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Summary

Caveolins are small integral membrane proteins with a vital role in the formation and function of caveolae. In this review, the role of caveolin-3, a predominantly muscle-specific member of the caveolin family, will be examined. We speculate that insights into the mechanism of caveolae formation may give clues into the formation of another plasma membrane domain, the transverse-tubule system of muscle cells and propose a role for cholesterol-enriched lipid “rafts” in this process. In addition, we review recent findings regarding caveolin-3 in differentiated muscle cells and, particularly, in dystrophic muscle.

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Abbreviations

DIG:

detergent-insoluble glycosphingolipid-enriched complex

DPC:

dystrophin protein complex

eNOS/nNOS:

endothelial/neuronal nitric oxide synthase

pTT:

precursor transverse tubule

T-tubule:

transverse tubule

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Authors and Affiliations

  1. Centre for Microscopy and Microanalysis, University of Queensland, 4072, Brisbane, Queensland, Australia

    R. G. Parton, A. Carozzi & J. Gustavsson

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  1. R. G. Parton
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  2. A. Carozzi
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  3. J. Gustavsson
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Parton, R.G., Carozzi, A. & Gustavsson, J. Caves and labyrinths: caveolae and transverse tubules in skeletal muscle. Protoplasma 212, 15–23 (2000). https://doi.org/10.1007/BF01279343

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